Rabbit Anti-Human Complement C8G Polyclonal Antibody(Cat#: CTA-426)

Name: Rabbit Anti-Human Complement C8G Polyclonal Antibody
SKU: CTA-426
Rating: 5 (1 reviews)

This product is an unconjugated anti-Human Complement C8G Polyclonal antibody generated from the Rabbit. The antibody can be used for WB; IHC.

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Datasheet

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Specifications

Clonality	Polyclonal
Host Animal	Rabbit
Isotype	IgG
Immunogen	This antibody was developed against Recombinant Protein corresponding to amino acids: STIQPKANFDAQQFAGTWLLVAVGSACRFLQEQGHRAEATTLHVAPQGTA MAVSTFRKLDGICWQVRQLYGDTGVLGRFLLQARGARGAVHVVVAET
Species Reactivity	Human
Applications	WB; IHC
Application Notes	WB: 0.04-0.4 µg/mL IHC: 1:20 - 1:50 The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Human complement C8G.
Purity	≥95% as determined by SDS-PAGE
Format	Liquid
Size	25; 100 µL
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Type	Primary Antibody

Target

Target Name	C8G
Alternative Names	C8C; complement component 8; gamma polypeptide; complement component C8 gamma chain; MGC142186
Gene ID	733
UniProt ID	P07360

Information

Introduction

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.