Rabbit Anti-Human Complement C8G Polyclonal Antibody(Cat#: CTA-426)
This product is an unconjugated anti-Human Complement C8G Polyclonal antibody generated from the Rabbit. The antibody can be used for WB; IHC.
Summary
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Specifications
| Clonality |
Polyclonal |
| Host Animal |
Rabbit |
| Isotype |
IgG |
| Immunogen |
This antibody was developed against Recombinant Protein corresponding to amino acids: STIQPKANFDAQQFAGTWLLVAVGSACRFLQEQGHRAEATTLHVAPQGTA MAVSTFRKLDGICWQVRQLYGDTGVLGRFLLQARGARGAVHVVVAET |
| Species Reactivity |
Human |
| Applications |
WB; IHC |
| Application Notes |
WB: 0.04-0.4 µg/mL
IHC: 1:20 - 1:50
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human complement C8G. |
| Purity |
≥95% as determined by SDS-PAGE |
| Format |
Liquid |
| Size |
25; 100 µL |
| Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Type |
Primary Antibody |
Target
| Target Name |
C8G |
| Alternative Names |
C8C; complement component 8; gamma polypeptide; complement component C8 gamma chain; MGC142186 |
| Gene ID |
733 |
| UniProt ID |
P07360 |
Information
| Introduction |
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
