Rabbit Anti-Human Ficolin-1 Polyclonal Antibody-CTA-1055(Cat#: CTA-1055)
This product is an unconjugated anti-Human Ficolin-1 Polyclonal antibody generated from the Rabbit. The antibody can be used for WB, IHC.
Summary
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Specifications
| Clonality |
Polyclonal |
| Host Animal |
Rabbit |
| Isotype |
IgG |
| Immunogen |
Recombinant human Ficolin-1, aa.: LAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD |
| Species Reactivity |
Human |
| Applications |
WB; IHC |
| Application Notes |
WB: 0.04-0.4 μg/mL
IHC: 1:200-1:500
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human Ficolin-1. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
Unconjugated |
| Format |
Liquid |
| Size |
25; 100 µL |
| Storage |
Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
| Type |
Primary Antibody |
Target
| Target Name |
Ficolin-1 |
| Alternative Names |
Ficolin 1; FCNM ; Ficolin-Alpha; Ficolin-1; M-Ficolin; Ficolin-A; Ficolin (Collagen/Fibrinogen Domain Containing) 1; FCN1 |
| Gene ID |
2219 |
| UniProt ID |
O00602 |
Information
| Introduction |
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
