Rabbit Anti-Human MASP-1 (Cleaved Arg448) Polyclonal Antibody(Cat#: CTA-1024)

This product is an unconjugated anti-Human MASP-1 (Cleaved Arg448) Polyclonal antibody generated from the Rabbit. The antibody can be used for WB.

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Summary

Specifications
Clonality Polyclonal
Host Animal Rabbit
Isotype IgG
Immunogen Recombinant human MASP1, a.a. 399-448
Species Reactivity Human
Applications WB
Application Notes WB: 1:500-1:1000
The optimal working dilutions should be determined by the end user.
Specificity This antibody reacts with Human MASP-1 (Cleaved Arg448).
Purity ≥95% as determined by SDS-PAGE
Conjugation Unconjugated
Format Liquid
Size 100 µg
Storage Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle.
Type Primary Antibody
Target
Target Name MASP-1 (Cleaved Arg448)
Alternative Names Mannan Binding Lectin Serine Peptidase 1; Complement-Activating Component Of Ra-Reactive Factor ; Mannose-Binding Lectin-Associated Serine Protease 1; C4/C2 Activating Component Of Ra-Reactive Factor ; Mannan-Binding Lectin Serine Protease 1; Ra-Reactive Factor Serine Protease P100; Complement Factor MASP-3; Serine Protease 5; CRARF1; CRARF; PRSS5; MASP; RaRF; MASP-1; MASP1; 3MC1; MAP1
Gene ID 5648
UniProt ID P48740
Information
Introduction Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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