Rat Anti-Human Complement C3c Monoclonal Antibody (CTJS-135)(Cat#: CTA-095)

Name: Rat Anti-Human Complement C3c Monoclonal Antibody (CTJS-135)
SKU: CTA-095
Rating: 5 (1 reviews)

This product is an unconjugated anti-Human Complement C3c Monoclonal antibody (CTJS-135) generated from the Rat. The antibody can be used for IP.

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Specifications

Clonality	Monoclonal
Clone	CTJS-135
Host Animal	Rat
Isotype	IgG2a
Immunogen	The monoclonal antibody 4 recognizes a conformational epitope in C3c, C3b and iC3b.
Species Reactivity	Human
Applications	IP
Application Notes	IP: 1:10-1:500 The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Human complement C3c.
Purity	≥95% as determined by SDS-PAGE
Format	Liquid
Size	25 µg
Storage	Store at 4°C. Do not freeze.
Type	Primary Antibody

Target

Target Name	C3c
Alternative Names	Complement C3c; C3c fragment
Gene ID	718
UniProt ID	P01024

Information

Introduction

Complement C3c is a cleaved product of complement C3. During the activation of complement system, C3 is cleaved into C3a and C3b fragments by C3 convertase. The C3b fragment can be degraded into iC3b when cleaved by complement factor I. iC3b serves as 'inactive' C3b unable to associate with complement factor B, which prevents amplification of the complement cascade through the alternative pathway. iC3b will be cleaved by trypsin-like enzymes releasing C3c and C3dg, and C3dg can be further cleaved into C3g and C3d.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.