Rat Anti-Mouse CD11b Monoclonal Antibody (CTJS-122)(Cat#: CTA-837)

Name: Rat Anti-Mouse CD11b Monoclonal Antibody (CTJS-122)
SKU: CTA-837
Rating: 5 (1 reviews)

This product is an unconjugated anti-Mouse CD11b Monoclonal antibody (CTJS-122) generated from the Rat. The antibody can be used for IP, IF, FC.

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Specifications

Clonality	Monoclonal
Clone	CTJS-122
Host Animal	Rat
Isotype	IgG2a
Immunogen	Mouse Integrin αM from Peritoneal macrophages from C57BL/6 x DBA/2 F1 hybrid mice
Species Reactivity	Mouse
Applications	IP; IF; FC
Application Notes	IP: 1-2 μg/mL IF: 1:50-1:500 FC: 1 µg/10^6 cells The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Mouse CD11b.
Purity	≥95% as determined by SDS-PAGE
Conjugation	Unconjugated
Format	Liquid
Size	100 µg
Storage	Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle.
Type	Primary Antibody

Target

Target Name	CD11b
Alternative Names	Integrin Subunit Alpha M; Complement Component 3 Receptor 3 Subunit; Integrin Alpha-M; CR-3 Alpha Chain; CD11B ; CR3A; Complement Component Receptor 3, Alpha; Neutrophil Adherence Receptor; Antigen; CD11b (P170); CD11b Antigen; ITGAM; CD11b
Gene ID	16409
UniProt ID	P05555

Information

Introduction

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.