Rat Anti-Mouse CR1/CR2 Monoclonal Antibody (CTJS-80) [FITC](Cat#: CTA-819)

Name: Rat Anti-Mouse CR1/CR2 Monoclonal Antibody (CTJS-80) [FITC]
SKU: CTA-819
Rating: 5 (1 reviews)

This product is a conjugated anti-Mouse CR1/CR2 Monoclonal antibody (CTJS-80) generated from the Rat. The antibody can be used for FC.

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Specifications

Clonality	Monoclonal
Clone	CTJS-80
Host Animal	Rat
Isotype	IgG2a κ
Immunogen	Purified CR1 from mouse serum
Species Reactivity	Mouse
Applications	FC
Application Notes	FC: 0.25 μg/10^6 cells The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Mouse CR1/CR2.
Purity	≥95% as determined by SDS-PAGE
Conjugation	FITC
Format	Liquid
Size	50; 500 µg
Storage	Store in dark at 4°C. Do Not Freeze.
Type	Primary Antibody

Target

Target Name	CR1/CR2
Alternative Names	Complement C3b/C4b Receptor 1 (Knops Blood Group); Complement Component (3b/4b) Receptor 1 (Knops Blood Group); Complement Receptor Type 1; C3b/C4b Receptor ; CD35 Antigen; C3BR; CD35; Complement Component 3b/4b Receptor 1; Knops Blood Group Antigen; Complement Receptor 1; C3-Binding Protein; C4BR; CR1; Complement C3d Receptor 2; C3DR; Complement Component (3d/Epstein Barr Virus) Receptor 2; Complement Component 3d Receptor 2; Epstein-Barr Virus Receptor; Complement Receptor Type 2; EBV Receptor; CD21; Complement C3d Receptor; CD21 Antigen; CVID7; CR2; Cr2
Gene ID	1378 1380
UniProt ID	P17927 P20023

Information

Introduction

CR1 serves as membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. It also acts as a receptor for Epstein-Barr virus.
CR2 is the receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU. It also participates in B lymphocytes activation and acts as a receptor for Epstein-Barr virus.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.