Rat Complement C4a ELISA Kit-CTK-232(Cat#: CTK-232)
This product is an ELISA kit for the determination of Rat Complement C4a in the samples of Serum, plasma and other biological fluids. It is highly sensitive and available for the detection of Rat Complement C4a as low as 0.145 ng/mL.
Summary
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Specifications
| Assay Type |
Sandwich ELISA |
| Sensitivity |
0.145 ng/mL (0.312-20n g/mL) |
| Pack Size |
96 tests |
| Species Reactivity |
Rat |
| Target |
C4a |
| Cross Reactivity |
No significant cross-reactions have been observed between Rat Complement C4a and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. |
| Applications |
ELISA |
| Storage |
The storage of components varies. Please refer to the instructions for details. |
Information
| Introduction |
Complement C4A is a non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
