Rat Complement C4b ELISA Kit-CTK-257(Cat#: CTK-257)
This product is an ELISA kit for the determination of Rat Complement C4b in the samples of Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate. It is highly sensitive and available for the detection of Rat Complement C4b as low as 25.6 pg/mL.
Summary
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Specifications
| Assay Type |
Sandwich ELISA |
| Sensitivity |
25.6 pg/mL (62.5-4000 pg/mL) |
| Pack Size |
96 tests |
| Species Reactivity |
Rat |
| Target |
C4b |
| Cross Reactivity |
No significant cross-reactions have been observed between Rat Complement C4b and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. |
| Applications |
ELISA |
| Storage |
The storage of components varies. Please refer to the instructions for details. |
Information
| Introduction |
Complement C4B is a non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
