Recombinant Anti-Human C5 Monoclonal Antibody (CTJS-536)(Cat#: CTA-543)
This product is an unconjugated anti-Human Complement C5 Monoclonal antibody (CTJS-536) generated from the Recombinant. The antibody can be used for ELISA.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-536 |
| Host Animal |
Recombinant |
| Isotype |
IgG2/4, κ |
| Immunogen |
Human Complement C5 |
| Species Reactivity |
Human |
| Applications |
ELISA |
| Application Notes |
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human Complement C5. |
| Purity |
≥98% as determined by SDS-PAGE |
| Conjugation |
Unconjugated |
| Format |
Liquid |
| Size |
200 µg |
| Storage |
Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
| Type |
Primary Antibody |
Target
| Target Name |
C5 |
| Alternative Names |
Complement C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement Component 5; C5a Anaphylatoxin; Prepro-C5; C5a; C5b; Anaphylatoxin C5a Analog; C5 |
| Gene ID |
727 |
| UniProt ID |
P01031 |
Information
| Introduction |
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
