Recombinant Anti-Human C5 Monoclonal Antibody (CTJS-536)(Cat#: CTA-543)

Name: Recombinant Anti-Human C5 Monoclonal Antibody (CTJS-536)
SKU: CTA-543
Rating: 5 (1 reviews)

This product is an unconjugated anti-Human Complement C5 Monoclonal antibody (CTJS-536) generated from the Recombinant. The antibody can be used for ELISA.

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Specifications

Clonality	Monoclonal
Clone	CTJS-536
Host Animal	Recombinant
Isotype	IgG2/4, κ
Immunogen	Human Complement C5
Species Reactivity	Human
Applications	ELISA
Application Notes	The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Human Complement C5.
Purity	≥98% as determined by SDS-PAGE
Conjugation	Unconjugated
Format	Liquid
Size	200 µg
Storage	Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle.
Type	Primary Antibody

Target

Target Name	C5
Alternative Names	Complement C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement Component 5; C5a Anaphylatoxin; Prepro-C5; C5a; C5b; Anaphylatoxin C5a Analog; C5
Gene ID	727
UniProt ID	P01031

Information

Introduction

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.