Recombinant Human CD11b Protein-N-terminal His and GST Tag-CTP-374(Cat#: CTP-374)

Name: Recombinant Human CD11b Protein-N-terminal His and GST Tag-CTP-374
SKU: CTP-374
Rating: 5 (1 reviews)

This product is a 55kDa recombinant human CD11b protein with a N-terminal His and GST Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB.

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Specifications

Expressed Host	E.coli
Specie Reactivity	Human
Target	CD11b
Molecule Mass	55kDa
Purity	>90 % determined by SDS-PAGE
Endotoxin	<1.0EU per 1µg (determined by the LAL method)
Formulation	20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300
Applications	Positive Control; Immunogen; WB
Product Form	Lyophilized
Storage	Store at -20°C/-80°C. Avoid freeze-thaw cycles.

Protein Information

Introduction	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
Alternative Names	Integrin Subunit Alpha M; Complement Component 3 Receptor 3 Subunit; Integrin Alpha-M; CR-3 Alpha Chain; CD11B ; CR3A; Complement Component Receptor 3, Alpha; Neutrophil Adherence Receptor; Antigen; CD11b (P170); CD11b Antigen; ITGAM; CD11b
Gene ID	3684
UniProt ID	P11215

For Research Use Only. Not for Diagnostic or Therapeutic Applications.