Recombinant Human CD11b Protein-N-terminal His Tag(Cat#: CTP-373)
This product is a 18kDa recombinant human CD11b protein with a N-terminal His Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB.
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Specifications
| Expressed Host |
E.coli |
| Specie Reactivity |
Human |
| Target |
CD11b |
| Molecule Mass |
18kDa |
| Purity |
>95 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300 |
| Applications |
Positive Control; Immunogen; WB |
| Product Form |
Lyophilized |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Alternative Names |
Integrin Subunit Alpha M; Complement Component 3 Receptor 3 Subunit; Integrin Alpha-M; CR-3 Alpha Chain; CD11B ; CR3A; Complement Component Receptor 3, Alpha; Neutrophil Adherence Receptor; Antigen; CD11b (P170); CD11b Antigen; ITGAM; CD11b |
| Gene ID |
3684 |
| UniProt ID |
P11215 |
Customer Review
Highly recommended for anyone in need of a reliable control for CD11b studies
Excellent
We used it as a positive control in our Western blot assays, and it performed exceptionally well. The protein demonstrated high purity and reproducibility, which was essential for validating our results.
High quality
Excellent
The His tag made it easy to purify, and the high-quality protein provided consistent results in our immunogen assays. It's evident that the protein was well-constructed and functional, making it a valuable tool for our lab.
A dependable choice for research applications
Excellent
We used this product for a series of immunoprecipitation experiments and were impressed with its performance. The protein's purity was evident from the gel analysis, and its ability to act as a positive control was exactly what we needed.
It's a great product
Excellent
I found this recombinant CD11b protein to be highly effective as an immunogen. The N-terminal His tag was well-placed, facilitating easy purification and handling. The protein showed strong reactivity in our Western blots, providing us with reliable and reproducible data. This product exceeded my expectations in both quality and functionality.
Using the protein in our experiments was a success
Excellent
The N-terminal His tag made the purification process smooth and efficient. We observed high purity and effective performance in our assays. The product's reliability and quality make it a valuable asset in any research lab.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
