Recombinant Human CD35 Protein-10His tag(Cat#: CTP-207)
This product is a 213 kDa recombinant human CD35 protein with a C-terminal 10-His tag expressed in the mouse myeloma cell line, NS0. It is available for Binding Activity Assays.
Summary
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Specifications
| Expressed Host |
Mouse myeloma cell line, NS0 |
| Specie Reactivity |
Human |
| Target |
CR1 |
| Molecule Mass |
213 kDa |
| Purity |
>90% by SDS-PAGE under reducing conditions and visualized by silver stain |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS |
| Applications |
Binding Activity Assays |
| Product Form |
Lyophilized |
| Storage |
Store at 2 to 8°C after reconstitution for short term (1-2 weeks). For long term storage, aliquot and store at -20 or -80°C. Avoid repeated freezing and thawing cycles. |
Protein Information
| Introduction |
Complement receptor type 1 ia a membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. It acts as a receptor for Epstein-Barr virus in microbial infection. |
| Alternative Names |
Complement C3b/C4b Receptor 1 (Knops Blood Group); Complement Component (3b/4b) Receptor 1 (Knops Blood Group); Complement Receptor Type 1; C3b/C4b Receptor; CD35 Antigen; C3BR; Complement Component (3b/4b) Receptor 1, Including Knops Blood Group System; Complement Component 3b/4b Receptor 1 (Knops Blood Group); Knops Blood Group Antigen; Complement Receptor 1; C3-Binding Protein; C4BR; CD35; KN |
| Gene ID |
1378 |
| UniProt ID |
P17927 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
