Recombinant Human CD46 Protein-His tag-CTP-212(Cat#: CTP-212)

Name: Recombinant Human CD46 Protein-His tag-CTP-212
SKU: CTP-212
Rating: 5 (1 reviews)

This product is a 33.8 kDa recombinant human CD46 protein with a N-Terminal His-tag expressed in the E.coli.

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Specifications

Expressed Host	E. Coli
Specie Reactivity	Human
Target	CD46
Molecule Mass	33.8 kDa
Purity	>85% by SDS-PAGE
Formulation	20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol
Product Form	Liquid
Storage	Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing.

Protein Information

Introduction	Membrane cofactor protein acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. In microbial infection, a number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. It also acts as a receptor for Adenovirus subgroup B2 and Ad3, a receptor for cultured Measles virus, a receptor for Herpesvirus 6/HHV-6, and a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes.
Alternative Names	CD46 Molecule; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Molecule, Complement Regulatory Protein; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; Membrane Cofactor Protein; MIC10; MCP; TLX; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; AHUS2
Gene ID	4179
UniProt ID	P15529

For Research Use Only. Not for Diagnostic or Therapeutic Applications.