Recombinant Human CD46 Protein-His tag-CTP-212(Cat#: CTP-212)
This product is a 33.8 kDa recombinant human CD46 protein with a N-Terminal His-tag expressed in the E.coli.
Summary
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Specifications
| Expressed Host |
E. Coli |
| Specie Reactivity |
Human |
| Target |
CD46 |
| Molecule Mass |
33.8 kDa |
| Purity |
>85% by SDS-PAGE |
| Formulation |
20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol |
| Product Form |
Liquid |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Membrane cofactor protein acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. In microbial infection, a number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. It also acts as a receptor for Adenovirus subgroup B2 and Ad3, a receptor for cultured Measles virus, a receptor for Herpesvirus 6/HHV-6, and a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes. |
| Alternative Names |
CD46 Molecule; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Molecule, Complement Regulatory Protein; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; Membrane Cofactor Protein; MIC10; MCP; TLX; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; AHUS2 |
| Gene ID |
4179 |
| UniProt ID |
P15529 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
