Recombinant Human CD59 Protein-10His tag(Cat#: CTP-219)
This product is a 10.3 kDa recombinant human CD59 protein with a C-terminal 10-His tag expressed in the mouse myeloma cell line, NS0. It is available for Bioactivity Assays.
Summary
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Specifications
| Expressed Host |
Mouse myeloma cell line, NS0 |
| Specie Reactivity |
Human |
| Target |
CD59 |
| Molecule Mass |
10.3 kDa |
| Purity |
>95% by SDS-PAGE under reducing conditions and visualized by silver stain |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS |
| Applications |
Bioactivity Assays |
| Product Form |
Lyophilized |
| Storage |
Store at 2 to 8°C after reconstitution for short term (1-2 weeks). For long term storage, aliquot and store at -20 or -80°C. Avoid repeated freezing and thawing cycles. |
Protein Information
| Introduction |
CD59 glycoprotein is a potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. |
| Alternative Names |
CD59 Molecule (CD59 Blood Group); CD59 Antigen P18-20 (Antigen Identified By Monoclonal Antibodies 16.3A5, EJ16, EJ30, EL32 And G344); CD59 Molecule, Complement Regulatory Protein; Membrane Attack Complex Inhibition Factor; Membrane Inhibitor Of Reactive Lysis; 20 KDa Homologous Restriction Factor; CD59 Glycoprotein; MEM43 Antigen; 1F5 Antigen; Protectin; HRF-20; MAC-IP; MIC11; MSK21; HRF20; Surface Anitgen Recognized By Monoclonal Antibody 16.3A5; Membrane Attack Complex (MAC) Inhibition Factor; CD59 Antigen, Complement Regulatory Protein; Lymphocytic Antigen CD59/MEM43; Human Leukocyte Antigen MIC11; T Cell-Activating Protein; CD59 Blood Group Antigen; MAC-Inhibitory Protein; Ly-6-Like Protein; CD59 Molecule; CD59 Antigen; 16.3A5; P18-20 |
| Gene ID |
966 |
| UniProt ID |
P13987 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
