Recombinant Human Complement C4A Protein-GST tag(Cat#: CTP-056)
This product is a recombinant human Complement C4A protein with a N-terminal GST tag with expressed in the Wheat Germ (in vitro). It is available for WB, ELISA, PA, AP.
Summary
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Specifications
| Expressed Host |
Wheat Germ (in vitro) |
| Specie Reactivity |
Human |
| Target |
C4a |
| Purity |
>80% by SDS-PAGE and Coomassie Blue staining |
| Formulation |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 |
| Applications |
WB; ELISA; PA; AP |
| Product Form |
Liquid |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Complement C4-A is a non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
| Alternative Names |
Complement C4A (Rodgers Blood Group); C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 2; Complement Component 4A (Rodgers Blood Group); Acidic Complement C4; CPAMD2; CO4; MHC Class III Region Complement; Complement Component 4A; Rodgers Form Of C4; C4A Anaphylatoxin; Complement C4-A; Acidic C4; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; C4; RG |
| Gene ID |
720 |
| UniProt ID |
P0C0L4 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
