Recombinant Human Complement C5 Protein-6His-ABP tag(Cat#: CTP-074)
This product is a 32 kDa recombinant human Complement C5 protein Antigen with a N-terminal His6-ABP tag expressed in the E. coli. It is available for Antibody Competition.
Summary
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Specifications
| Expressed Host |
E. Coli |
| Specie Reactivity |
Human |
| Target |
C5 |
| Molecule Mass |
32 kDa |
| Purity |
>80% by SDS-PAGE and Coomassie Blue staining |
| Formulation |
PBS and 1M Urea, pH 7.4 |
| Applications |
AC |
| Product Form |
Liquid |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
| Alternative Names |
Complement C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement Component 5; C5a Anaphylatoxin; Prepro-C5; CPAMD4; Anaphylatoxin C5a Analog; ECLZB; C5D; C5a; C5b |
| Gene ID |
727 |
| UniProt ID |
P01031 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
