Recombinant Human Complement C5 Protein-a polyhistidine tag at the C-terminus and a FLAG tag at the N-terminus(Cat#: CTP-264)

Name: Recombinant Human Complement C5 Protein-a polyhistidine tag at the C-terminus and a FLAG tag at the N-terminus
SKU: CTP-264
Rating: 5 (1 reviews)

This product is a 188.8 kDa recombinant human C5 protein with a a polyhistidine tag at the C-terminus and a FLAG tag at the N-terminus tag expressed in the HEK293 Cells. It is availible for WB, IA.

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Specifications

Expressed Host	HEK293 Cells
Specie Reactivity	Human
Target	C5
Molecule Mass	188.8 kDa
Purity	>95 % determined by SDS-PAGE
Endotoxin	<1.0EU per 1µg (determined by the LAL method)
Formulation	PBS, pH 7.4, and 5 % - 8 % trehalose, mannitol and 0.01% Tween80
Applications	WB; IA
Product Form	Lyophilized
Storage	Store at -20°C/-80°C. Avoid freeze-thaw cycles.

Protein Information

Introduction	Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Alternative Names	Complement C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement Component 5; C5a Anaphylatoxin; Prepro-C5; C5a; C5b; Anaphylatoxin C5a Analog; C5
Gene ID	727
UniProt ID	P01031

For Research Use Only. Not for Diagnostic or Therapeutic Applications.