Recombinant Human Complement C5 Protein-GST tag(Cat#: CTP-073)
This product is a recombinant human Complement C5 protein with a N-terminal GST tagWheat Germ (in vitro) with expressed in the Wheat Germ (in vitro). It is available for WB, ELISA, PA, AP.
Summary
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Specifications
Expressed Host |
Wheat Germ (in vitro) |
Specie Reactivity |
Human |
Target |
C5 |
Purity |
>80% by SDS-PAGE and Coomassie Blue staining |
Formulation |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 |
Applications |
WB; ELISA; PA; AP |
Product Form |
Liquid |
Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
Introduction |
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
Alternative Names |
Complement C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement Component 5; C5a Anaphylatoxin; Prepro-C5; CPAMD4; Anaphylatoxin C5a Analog; ECLZB; C5D; C5a; C5b |
Gene ID |
727 |
UniProt ID |
P01031 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.