Recombinant Human Complement C5 Protein-GST tag(Cat#: CTP-073)

Name: Recombinant Human Complement C5 Protein-GST tag
SKU: CTP-073
Rating: 5 (1 reviews)

This product is a recombinant human Complement C5 protein with a N-terminal GST tagWheat Germ (in vitro) with expressed in the Wheat Germ (in vitro). It is available for WB, ELISA, PA, AP.

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Specifications

Expressed Host	Wheat Germ (in vitro)
Specie Reactivity	Human
Target	C5
Purity	>80% by SDS-PAGE and Coomassie Blue staining
Formulation	50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0
Applications	WB; ELISA; PA; AP
Product Form	Liquid
Storage	Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing.

Protein Information

Introduction	Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Alternative Names	Complement C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement Component 5; C5a Anaphylatoxin; Prepro-C5; CPAMD4; Anaphylatoxin C5a Analog; ECLZB; C5D; C5a; C5b
Gene ID	727
UniProt ID	P01031

For Research Use Only. Not for Diagnostic or Therapeutic Applications.