Recombinant Human Complement Factor I Protein-N-terminal His and GST Tag(Cat#: CTP-321)
This product is a recombinant human Factor I protein with a N-terminal His and GST Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB.
Summary
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Specifications
| Expressed Host |
E.coli |
| Specie Reactivity |
Human |
| Target |
Factor I |
| Purity |
>95 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300 |
| Applications |
Positive Control; Immunogen; WB |
| Product Form |
Lyophilized |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. |
| Alternative Names |
Complement Factor I; Konglutinogen-Activating Factor; C3B/C4B Inactivator; C3b-Inactivator; C3b-INA; Complement Control Protein Factor I; Complement Factor I Heavy Chain; Light Chain Of Factor I; Complement Component I; I Factor (Complement); CFI |
| Gene ID |
3426 |
| UniProt ID |
P05156 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
