Recombinant Human Complement MASP3 Catalytic Domain-10His tag(Cat#: CTP-241)
This product is a 31 kDa recombinant human Complement MASP3 Catalytic Domain with a C-terminal 10-His tag expressed in the mouse myeloma cell line, NS0. It is available for Enzyme Activity Assays.
Summary
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Specifications
| Expressed Host |
Mouse myeloma cell line, NS0 |
| Specie Reactivity |
Human |
| Target |
MASP3 |
| Molecule Mass |
31 kDa |
| Purity |
>95% by SDS-PAGE under reducing conditions and visualized by silver stain |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
Tris, NaCl and CaCl2 |
| Applications |
Enzyme Activity Assays |
| Product Form |
Liquid |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Mannan-binding lectin serine protease 1 functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development. |
| Alternative Names |
Mannan Binding Lectin Serine Peptidase 1; Complement-Activating Component Of Ra-Reactive Factor; Mannose-Binding Lectin-Associated Serine Protease 1; Mannose-Binding Protein-Associated Serine Protease; C4/C2 Activating Component Of Ra-Reactive Factor; Mannan-Binding Lectin Serine Protease 1; Ra-Reactive Factor Serine Protease P100; Mannan-Binding Lectin Serine Peptidase 1 (C4/C2 Activating Component Of Ra-Reactive Factor); Complement Factor MASP-3; Serine Protease 5; CRARF1; CRARF; PRSS5; RaRF;MASP-1; MASP3; MAp44; MAP1; MASP |
| Gene ID |
5648 |
| UniProt ID |
P48740 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
