Recombinant Human CR1 Protein-N-terminal GST-tagged(Cat#: CTP-368)
This product is a recombinant human CR1 protein with a N-terminal GST-tagged tag expressed in the E.coli. It is availible for WB, ELISA.
Summary
Related Products & Services
Specifications
| Expressed Host |
E.coli |
| Specie Reactivity |
Human |
| Target |
CR1 |
| Purity |
>90 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
Tris-base, 50% glycerol |
| Applications |
WB; ELISA |
| Product Form |
Liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells.
Acts as a receptor for Epstein-Barr virus. |
| Alternative Names |
Complement C3b/C4b Receptor 1 (Knops Blood Group); Complement Component (3b/4b) Receptor 1 (Knops Blood Group); Complement Receptor Type 1; C3b/C4b Receptor ; CD35 Antigen; C3BR; CD35; Complement Component 3b/4b Receptor 1; Knops Blood Group Antigen; Complement Receptor 1; C3-Binding Protein; C4BR; CR1 |
| Gene ID |
1378 |
| UniProt ID |
P17927 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
