This product is a 27kDa recombinant human Ficolin 1 protein with a N-terminal His Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB.
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| Expressed Host | E.coli |
| Specie Reactivity | Human |
| Target | Ficolin-1 |
| Molecule Mass | 27kDa |
| Purity | >95 % determined by SDS-PAGE |
| Endotoxin | <1.0EU per 1µg (determined by the LAL method) |
| Formulation | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300 |
| Applications | Positive Control; Immunogen; WB |
| Product Form | Lyophilized |
| Storage | Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
| Introduction | Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. |
| Alternative Names | Ficolin 1; FCNM ; Ficolin-Alpha; Ficolin-1; M-Ficolin; Ficolin-A; Ficolin (Collagen/Fibrinogen Domain Containing) 1; FCN1 |
| Gene ID | 2219 |
| UniProt ID | O00602 |