Recombinant Human ITGAM Protein-GST tag(Cat#: CTP-191)
This product is a 37.84 kDa recombinant human ITGAM protein with a N-terminal GST tag expressed in the Wheat Germ. It is available for WB, ELISA, PA, AP.
Summary
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Specifications
| Expressed Host |
Wheat Germ |
| Specie Reactivity |
Human |
| Target |
CD11b |
| Molecule Mass |
37.84 kDa |
| Purity |
>80% by SDS-PAGE and Coomassie Blue staining |
| Formulation |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 |
| Applications |
WB; ELISA; PA; AP |
| Product Form |
Liquid |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Alternative Names |
Integrin Subunit Alpha M; Integrin Alpha-M; Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit); Cell Surface Glycoprotein MAC-1 Subunit Alpha; Complement Component 3 Receptor 3 Subunit; D11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; CR-3 Alpha Chain; CD11B; CR3A; Neutrophil Adherence Receptor Alpha-M Subunit; Macrophage Antigen Alpha Polypeptide; Neutrophil Adherence Receptor; Antigen CD11b (P170); CD11b Antigen; MAC-1; MAC1A; SLEB6; MO1A |
| Gene ID |
3684 |
| UniProt ID |
P11215 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
