Recombinant Human ITGAM Protein-MYC/DDK tag(Cat#: CTP-190)

Name: Recombinant Human ITGAM Protein-MYC/DDK tag
SKU: CTP-190
Rating: 5 (1 reviews)

This product is a 125.4 kDa recombinant human ITGAM protein with a C-MYC/DDK tag expressed in the HEK293T Cells. It is available for WB, ELISA, PA.

INQUIRY

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number

TOP

Summary Related Products & Services

Specifications

Expressed Host	HEK293T Cells
Specie Reactivity	Human
Target	CD11b
Molecule Mass	125.4 kDa
Purity	>80% as determined by SDS-PAGE and Coomassie Blue staining
Formulation	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Applications	WB; ELISA; PA
Product Form	Liquid
Storage	Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing.

Protein Information

Introduction	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
Alternative Names	Integrin Subunit Alpha M; Integrin Alpha-M; Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit); Cell Surface Glycoprotein MAC-1 Subunit Alpha; Complement Component 3 Receptor 3 Subunit; D11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; CR-3 Alpha Chain; CD11B; CR3A; Neutrophil Adherence Receptor Alpha-M Subunit; Macrophage Antigen Alpha Polypeptide; Neutrophil Adherence Receptor; Antigen CD11b (P170); CD11b Antigen; MAC-1; MAC1A; SLEB6; MO1A
Gene ID	3684
UniProt ID	P11215

For Research Use Only. Not for Diagnostic or Therapeutic Applications.