Recombinant Human ITGB2 Protein-His tag(Cat#: CTP-197)
This product is a 75.9 kDa recombinant human ITGB2 protein with a C-Terminal His-tag expressed in the Baculovirus.
Summary
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Specifications
| Expressed Host |
Baculovirus |
| Specie Reactivity |
Human |
| Target |
CD18 |
| Molecule Mass |
75.9 kDa |
| Purity |
>85% by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
Phosphate Buffered Saline (pH 7.4) containing 10% glycerol |
| Product Form |
Liquid |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. |
| Alternative Names |
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18; Leukocyte Cell Adhesion Molecule CD18; Complement Receptor C3 Beta-Subunit; Macrophage Antigen 1 (Mac-1) Beta Subunit); LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1 |
| Gene ID |
3689 |
| UniProt ID |
P05107 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
