Recombinant Human MASP1 Protein-6His tag(Cat#: CTP-240)

Name: Recombinant Human MASP1 Protein-6His tag
SKU: CTP-240
Rating: 5 (1 reviews)

This product is a recombinant human MASP1 protein with a 6His tag at the C-terminus expressed in the Human Cells.

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Specifications

Expressed Host	Human Cells
Specie Reactivity	Human
Target	MASP1
Purity	>95% as determined by reducing SDS-PAGE
Endotoxin	<1.0EU per 1µg (determined by the LAL method)
Formulation	20 mM Tris, 200 mM NaCl, 10% Glycerol, pH 8.0
Product Form	Liquid
Storage	Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing.

Protein Information

Introduction	Mannan-binding lectin serine protease 1 functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.
Alternative Names	Mannan Binding Lectin Serine Peptidase 1; Complement-Activating Component Of Ra-Reactive Factor; Mannose-Binding Lectin-Associated Serine Protease 1; Mannose-Binding Protein-Associated Serine Protease; C4/C2 Activating Component Of Ra-Reactive Factor; Mannan-Binding Lectin Serine Protease 1; Ra-Reactive Factor Serine Protease P100; Mannan-Binding Lectin Serine Peptidase 1 (C4/C2 Activating Component Of Ra-Reactive Factor); Complement Factor MASP-3; Serine Protease 5; CRARF1; CRARF; PRSS5; RaRF;MASP-1; MASP3; MAp44; MAP1; MASP
Gene ID	5648
UniProt ID	P48740

For Research Use Only. Not for Diagnostic or Therapeutic Applications.