Recombinant Mouse Itgb2 Protein-His tag(Cat#: CTP-202)
This product is a 28 kDa recombinant mouse Itgb2 protein with a His tag at N-terminus expressed in the E. Coli. It is available for WB, ELISA, IP.
Summary
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Specifications
| Expressed Host |
E. Coli |
| Specie Reactivity |
Mouse |
| Target |
CD18 |
| Molecule Mass |
28 kDa |
| Purity |
>95% as determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
20mM Tris, 150mM NaCl, pH 8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin 300 |
| Applications |
WB; ELISA; IP |
| Product Form |
Lyophilized |
| Storage |
Store at 2 to 8°C after reconstitution for short term (1-2 weeks). For long term storage, aliquot and store at -20 or -80°C. Avoid repeated freezing and thawing cycles. |
Protein Information
| Introduction |
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. Integrin ITGAM/ITGB2 plays a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the ITGAM subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity. |
| Alternative Names |
Integrin Subunit Beta 2; Integrin, Beta 2 (Complement Component 3 Receptor 3 And 4 Subunit); Complement Component 3 Receptor 3 And 4 Subunit; Integrin Beta-2; CD18; MFI7; Cell Surface Adhesion Glycoprotein (LFA-1/CR3/P150,959 Beta Subunit Precursor); Cell Surface Adhesion Glycoproteins LFA-1/CR3/P150,95 Subunit Beta; Leukocyte-Associated Antigens CD18/11A, CD18/11B, CD18/11C; Leukocyte Cell Adhesion Molecule CD18; Complement Receptor C3 Beta-Subunit; Complement Receptor C3 Subunit Beta; Integrin Beta Chain, Beta 2;CD18 Antigen; LCAMB; LFA-1; MAC-1; MF17; LAD |
| Gene ID |
16414 |
| UniProt ID |
P11835 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
