Recombinant Rat C1qBP Protein-His tag(Cat#: CTP-013)
This product is a 25.0 kDa recombinant rat C1qBP protein with a N-terminal His-Tag expressed in the E. Coli. It is available for WB, ELISA, IP.
Summary
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Specifications
| Expressed Host |
E. Coli |
| Specie Reactivity |
Rat |
| Target |
C1qBP |
| Molecule Mass |
25.0 kDa |
| Purity |
>95% as determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS, pH 7.4, containing 5% sucrose, 0.01% sarcosyl |
| Applications |
WB; ELISA; IP |
| Product Form |
Lyophilized |
| Storage |
Store at 2 to 8°C after reconstitution for short term (1-2 weeks). For long term storage, aliquot and store at -20 or -80°C. Avoid repeated freezing and thawing cycles. |
Protein Information
| Introduction |
C1qBP is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. It acts as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades at the cell surface. It is a putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. It is a high affinity receptor for kininogen-1/HMWK in complex with cytokeratin-1/KRT1. The secreted form of C1qBP may enhance both extrinsic and intrinsic coagulation pathways. It also involves in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection; HIV-1 replication, presumably by contributing to splicing of viral RNA; infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A; and replication of Rubella virus. |
| Alternative Names |
Complement component 1 Q subcomponent-binding protein, mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; Gc1qbp; C1qBP |
| Gene ID |
29681 |
| UniProt ID |
O35796 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
