Recombinant Rat CD11b Protein-N-terminal His Tag-CTP-375(Cat#: CTP-375)
This product is a 16.7kDa recombinant rat CD11b protein with a N-terminal His Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB.
Summary
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Specifications
| Expressed Host |
E.coli |
| Specie Reactivity |
Rat |
| Target |
CD11b |
| Molecule Mass |
16.7kDa |
| Purity |
>95 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300 |
| Applications |
Positive Control; Immunogen; WB |
| Product Form |
Lyophilized |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Alternative Names |
Integrin Subunit Alpha M; Complement Component 3 Receptor 3 Subunit; Integrin Alpha-M; CR-3 Alpha Chain; CD11B ; CR3A; Complement Component Receptor 3, Alpha; Neutrophil Adherence Receptor; Antigen; CD11b (P170); CD11b Antigen; ITGAM; CD11b |
| Gene ID |
25021 |
| UniProt ID |
G3V8L7 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
