Recombinant Rat CD46 Protein-N-terminal His and GST Tag(Cat#: CTP-335)
This product is a 53kDa recombinant rat CD46 protein with a N-terminal His and GST Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB.
Summary
Related Products & Services
Specifications
| Expressed Host |
E.coli |
| Specie Reactivity |
Rat |
| Target |
CD46 |
| Molecule Mass |
53kDa |
| Purity |
>90 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300 |
| Applications |
Positive Control; Immunogen; WB |
| Product Form |
Lyophilized |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
Acts as a receptor for Adenovirus subgroup B2 and Ad3.
Acts as a receptor for cultured Measles virus.
Acts as a receptor for Herpesvirus 6/HHV-6.
May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes. |
| Alternative Names |
CD46 Molecule; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Molecule, Complement Regulatory Protein; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; Membrane Cofactor Protein; MCP; Trophoblast-Lymphocyte Cross-Reactive Antigen; Complement Membrane Cofactor Protein; Trophoblast Leucocyte Common Antigen; Measles Virus Receptor; CD46 Antigen; CD46 |
| Gene ID |
29333 |
| UniProt ID |
Q9Z0M4 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
