Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe SLC31 (CTR) family of copper transporters consists of two members of human, CTR1, and CTR2, which are encoded in the human genome by the SLC31A1 and SLC31A2 genes, respectively. They are expressed in all tissues and organs examined, with high levels in the liver and kidney. Excess copper accumulation in cells over-expressing human CTR1 indicates that it is a limiting factor for cellular copper acquisition. However, unlike CTR1, human CTR2 expression levels do not result in significant changes in cellular copper metabolism.
One to six SLC31 family members have been identified in each eukaryote with some subcellular and/or organ specificities. The subcellular localization of CTR1 is different in mammalian cell lines. Most of the CTR1 in human embryonic kidney (HEK 293) cells are localized at the plasma membrane such as yCTR1 in yeast. However, in some cell lines, including lung cancer cell lines (A549 and H441), and hepatocellular carcinoma cell line (HepG2), CTR1 is predominantly in the cytoplasmic vesicular compartments.
Copper is an important mineral in many organisms, but it is highly toxic, as demonstrated by serious health concerns related to its deficiency or excess accumulation. The SLC31 family of copper transporters is the primary gateway of copper acquisition in eukaryotes, from yeast to humans. Function, modes of action, and regulation of CTR and other molecular factors have revealed that organisms have evolved fascinating mechanisms for tight control of copper metabolism. These factors functionally cooperate with CTR for copper transport, compartmentalization, incorporation into cuproproteins, and detoxification.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
