Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Corticotropin releasing hormone receptor 1 |
| Gene Name | CRHR1 |
| Uniprot | P34998 (Human); P35347 (Mouse) |
| Synonym | CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRF-R-1; CRH-R-1; corticotropin-releasing factor type 1 receptor; seven transmembrane helix receptor |
| Background | CRHR1, encoded by CRHR1 gene, also known as CRF1, is a cell-surface protein. It belongs to G-protein coupled receptor family which has seven transmembrane domains. CRHR1 is located at 17q12-q22. The molecular weight of CRHR1 is 50,719 in human. The extracellular domain of receptor responds to peptide hormones, corticotropin-releasing hormone (CRH) and urocortin (UCN), involved in the regulation of response to stress. Most studies have been designed to investigate the CRHR1 possible role in regulation response to stress and in potential drug targets for depression and anxiety. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX285 | NativeExtract™ Human CRHR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3558K | MemDX™ Membrane Protein Human CRHR1 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0267X | MemDX™ Membrane Protein Human CRHR1 (Corticotropin releasing hormone receptor 1) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MPX4479K | MemDX™ Membrane Protein Human CRHR1 Expressed in E.coli with GST tag at the N-terminus, Partial (24-121aa) | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
M**y: I recently purchased the CRHR1 protein from Creative Biolabs and I must say, I am thoroughly impressed with the quality and performance of this product.
18/Sep/2023
R***rt: The shipping was efficient and the packaging ensured that the protein arrived in perfect condition.
24/Jun/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
PCR Amplification and Sanger Sequencing
Creative Biolabs offers PCR amplification and sanger sequencing services. The methodology employed involved the robust application of polymerase chain reaction (PCR) amplification, subsequently coupled with Sanger sequencing. This dual-pronged approach meticulously interrogated all fourteen exons comprising the CRHR1 coding sequence, alongside a segment of its contiguous 5′ flanking regulatory region. Such a rigorous genetic interrogation is fundamentally instrumental, perhaps even indispensable, for the precise discernment of single nucleotide polymorphisms and other sequence variations harbored within the CRHR1 locus.
Gene Expression Analysis
Creative Biolabs offers gene expression analysis services. In investigations concerning the mechanistic underpinnings of CRHR1 activity, the comprehensive analysis of global gene expression patterns in CRH-stimulated cellular systems can be judiciously undertaken. This approach serves to delineate the full repertoire of genes whose transcriptional regulation is directly or indirectly modulated by CRHR1 activation. This analysis involved the concerted application of both supervised and unsupervised algorithmic methodologies, allowing for robust pattern recognition and the identification of differentially expressed transcripts. Such a sophisticated analytical framework is demonstrably instrumental; indeed, it is perhaps indispensable for the comprehensive elucidation of CRHR1-dependent intracellular signaling cascades.
Pharmacogenetics and Treatment Response
Creative Biolabs offers pharmacogenetics and treatment response services. Compelling evidence emanating from pharmacogenetic investigations has consistently illuminated statistically significant associations between polymorphisms within the CRHR1 gene and differential therapeutic responses to a diverse array of antidepressant treatments. By meticulously scrutinizing the genetic variations inherent to CRHR1 and subsequently delineating their precise impact on patient outcomes following pharmacological intervention, researchers can endeavor to advance the paradigm of personalized medicine. Such efforts are critical, for they hold the promise of developing highly tailored, gene-informed therapeutic strategies that demonstrably enhance efficacy within specific, genetically defined patient cohorts.
Creative Biolabs offers comprehensive and innovative services to drive the development of CRHR1 cell therapy. Please for more services.
Neural Progenitor Cell
Creative Biolabs offers neural progenitor cell research services. The deliberate overexpression of CRHR1 consistently resulted in a discernible enhancement of neurosphere formation, a recognized proxy for neural stem cell proliferation and self-renewal in vitro. Concomitantly, an observable upregulation in the expression of SOX2, a pivotal transcription factor indicative of neural stemness, was detected. Conversely, experimental manipulations designed to achieve CRHR1 knockdown yielded precisely antithetical outcomes; that is, a marked reduction in both neurosphere-generating capacity and SOX2 transcriptional levels was observed. Collectively, these empirical findings provide compelling evidence supporting a crucial, perhaps even indispensable, role for CRHR1 in the intricate regulation of neural stem cell fate and proliferation.
DREADD Receptor Targeting
Creative Biolabs offers DREADD receptor targeting development services. In investigations aimed at elucidating the functional contributions of specific neuronal populations, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) present a powerful chemogenetic approach. In a notable application of this technique, DREADD receptors were precisely targeted for expression within CRHR1-positive (CRHR1+) neurons located in the central amygdala (CeA). This methodological advancement is profoundly significant; it confers an unprecedented level of precise pharmacological manipulation over neuronal activity within a defined cell population. Consequently, this innovative tool offers a critical avenue for systematically dissecting the multifaceted functional roles of CRHR1+ neurons within complex behavioral circuits.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
