Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-X-C motif chemokine receptor 1 |
| Gene Name | CXCR1 |
| Uniprot | P25024 (Human); Q810W6 (Mouse) |
| Synonym | C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1; C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; IL-8 receptor type 1; IL-8R A; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A |
| Background | CXCR1, also known as Interleukin 8 receptor, belongs to a subfamily of chemokine receptors from a large family of G protein-coupled receptor, encoded by CXCR1 gene. There are currently seven CXC chemokine receptors in mammals, termed CXCR1-CXCR7. The receptor can recognize CXC chemokine that possesses an E-L-R amino acid motif. Recently, most studies have been made to investigate the CXCR1 role in the treatment of cancer. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX403 | NativeExtract™ Human CXCR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MP1343J | MemDX™ Membrane Protein Human CXCR1 (C-X-C motif chemokine receptor 1) for Antibody Discovery | E.coli cell-free | Full length | Detergent |
| MP0276X | MemDX™ Membrane Protein Human CXCR1 (C-X-C motif chemokine receptor 1) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0275X | MemDX™ Membrane Protein Human CXCR1 (C-X-C motif chemokine receptor 1) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| S01YF-0423-KX480 | MemDX™ Membrane Protein Human CXCR1 (1-39aa) Expressed in HEK293, C-Human Fc tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
S***n: I recently purchased protein products from Creative Biolabs for my research project, and I must say that my overall experience has been highly satisfactory.
22/Sep/2023
Je****er: The proteins I received from Creative Biolabs exhibited exceptional purity levels. The consistency in purity across different batches is also noteworthy, which gives me confidence in the reliability of the products for long-term research.
17/Jul/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Single-Cell RNA Sequencing
Creative Biolabs offers single-cell RNA sequencing services. The intricate interplay of cellular components within the tumor microenvironment profoundly influences therapeutic outcomes in neoplastic diseases. This sophisticated methodological paradigm necessitates the meticulous preparation and disaggregation of tumor biopsy specimens, followed by high-throughput transcriptional profiling at the individual cellular level. Such granular resolution permits the unequivocal identification and quantitative assessment of distinct cellular populations, including various neutrophil phenotypes, based on their unique transcriptomic signatures. Through this advanced bioinformatic approach, investigators can infer the developmental progression of neutrophils within the tumor milieu, thereby perhaps discerning their dynamic roles in modulating anti-tumor immune responses and, consequently, influencing therapeutic efficacy. This multifaceted analytical framework offers a robust platform for unraveling the complex cellular dynamics that underpin resistance or sensitivity to targeted oncological interventions.
Promoter Engineering for Specificity
Creative Biolabs offers promoter engineering services. In the burgeoning field of gene therapy, particularly concerning targeted interventions for oncological pathologies, the precise manipulation of gene expression via promoter engineering constitutes a critically important technological advance. This methodological cornerstone is demonstrably pivotal in the rational design and subsequent development of therapeutic strategies. For instance, the intrinsic regulatory elements of the CXCR1 gene, specifically its promoter region, have been strategically harnessed to direct the transcriptional activation of cytotoxic effector molecules, thereby achieving cell-type-specific protein synthesis exclusively within malignant cellular populations. This highly refined regulatory mechanism is instrumental in ensuring that the therapeutic payload—the gene product responsible for cytotoxic activity—is transcribed and translated solely within the designated neoplastic cells. Such spatial restriction of transgene expression inherently minimizes inadvertent off-target effects on healthy tissues.
Creative Biolabs offers comprehensive and innovative services to drive the development of CXCR1 cell therapy. Please for more services.
CXCR1 as a Cancer Stem Cell Marker
Creative Biolabs offers cancer stem cell marker development services. Emerging evidence suggests that CXCR1 functions as a putative biomarker for cancer stem cells (CSCs) within the highly aggressive context of pancreatic ductal adenocarcinoma (PDAC). Investigations have rigorously demonstrated a compelling association between the expression of this specific chemokine receptor, CXCR1, and the presence of other well-established CSC surrogates, notably CD44 and CD133. Moreover, a growing body of in vitro and in vivo studies has systematically elucidated the functional significance of this axis. Specifically, the pharmacological or genetic perturbation of the CXCR1 signaling pathway has been shown to profoundly attenuate the proliferative capacity of tumorspheres, a hallmark of CSC activity, and concomitantly inhibit the migratory and invasive capabilities characteristic of PDAC cellular populations.
CXCR1-Modified CAR T Cells
Creative Biolabs offers CXCR1-modified CAR-T cells development services. Beyond conventional strategies, a highly promising avenue in adoptive cellular immunotherapy involves the sophisticated genetic engineering of CAR-T lymphocytes through the incorporation of CXCR1. This innovative modification is designed to augment their intrinsic capacity for precise targeting of malignant cellular entities. Specifically, this strategic manipulation entails re-programming CAR-T cells to effectively co-opt interleukin-8 (IL-8), a chemokine often aberrantly expressed within the tumor microenvironment, thereby orchestrating maximal anti-neoplastic effector functions. The therapeutic potency of these engineered CAR-T cells has been rigorously evaluated across a diverse array of preclinical tumor models, which has consistently demonstrated their significant potential as a transformative modality in contemporary cancer therapeutics.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
