Introduction of CXCR1
CXCR1, also known as Interleukin 8 receptor, belongs to a subfamily of chemokine receptors from a large family of G protein-coupled receptor, encoded by CXCR1 gene. There are currently seven CXC chemokine receptors in mammals, termed CXCR1-CXCR7. The receptor can recognize CXC chemokine that possesses an E-L-R amino acid motif. Recently, most studies have been made to investigate the CXCR1 role in the treatment of cancer.
|Basic Information of CXCR1|
|Protein Name||C-X-C chemokine receptor type 1|
|Aliases||V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1|
|Organism||Homo sapiens (Human)|
Function of CXCR1 Membrane Protein
CXCR1 mainly exist on the surface of neutrophils in mammals and can bind to Interleukin 8 with high affinity as well as activate a phosphatidylinositol-calcium second messenger system, mediating the activation of neutrophils. In mice, the deficiency of CXCR1 can suppress embryonic oligodendrocyte precursor migration in developing spinal cord. Moreover, most studies have shown that the overexpression of CXCR1 can be considered as a biomarker for many solid tumors, such as gastric adenocarcinoma and breast cancer. And CXCR1 is associated with drug-resistance, invasion, and metastasis in various tumors. In view of the functions of CXCR1 in progression of tumors, CXCR1 and its related pathways may be regarded as a promising target for cancer treatment. Recent studies have shown that CXCR1/2 antagonists are the promising therapeutic reagents for treating pancreatic cancer. Moreover, the CXCR1 level can be considered as an independent prognosticator in metastatic renal cell carcinoma.
Fig.1 CXCR1/2 receptor/ligand signaling pathways in gastric carcinoma. (Wang, 2013)
Application of CXCR1 Membrane Protein in Literature
The study is aimed to identify the correlation of interleukin 8-receptor gene polymorphisms and urinary tract infection (UTI) susceptibility using meta-analyses. Results show that rs2234671 polymorphism in gene CXCR1 may increase the risk of urinary tract infection (UTI) in children.
The study shows that CXCR1/2 antagonists, reparixin or SCH527123, inhibit CXCR1/2-mediated signal transduction, reducing the growth and migration of human pancreatic cancer cells. Hence reparixin and SCH527123 may be potential therapeutic drugs for treating pancreatic cancer.
In this research, authors indicate that high CXCR1 expression is an independent prognosticator in metastatic renal cell carcinoma. The high CXCR1 expression may be associated with decreased benefit from tyrosine kinase inhibitors (TKIs) therapy and the outcome may be induced by the enriched pathways of hypoxia and angiogenesis in CXCR1 positive patients.
The research is designed to study the prognostic significance of CXCR1 in patients with non-metastatic clear cell renal cell carcinoma (ccRCC). Results reveal that increased epithelial CXCR1 levels are significantly associated with overall survival (OS) in all non-metastatic ccRCC patients. Hence high epithelial CXCR1 may act as an independent negative prognostic factor in non-metastatic ccRCC patients.
The study shows that the inhibitor of CXCR1/2 protects organism from inflammatory response during respiratory influenza and pneumococcal infections. Hence authors put forward a new therapeutic strategy for treating lung infections caused by influenza, pneumococcal, and post-influenza pneumococcal infections.
CXCR1 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CXCR1 antibody development services.
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