Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-X-C motif chemokine receptor 3 |
| Gene Name | CXCR3 |
| Uniprot | P49682 (Human); O88410 (Mouse) |
| Synonym | GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; G protein-coupled receptor 9; IP-10 receptor; Mig receptor; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; interferon-inducible protein 10 receptor |
| Background | CXCR3 is a G protein-coupled receptor in the CXC chemokine receptor family, encoded by CXCR3 gene. It is one of seven CXC chemokine receptors (CXCR1-CXCR7) in mammals. The receptors can recognize CXC chemokine that possesses an E-L-R amino acid motif. CXCR3 is widely expressed in many human tissues, such as lymph node, spleen. Recently, most studies focus on the role of CXCR3 in the pathological process of cancer. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX431 | NativeExtract™ Human CXCR3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPVLP-013 | MemDX™ Recombinant Human CXCR3 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MP1345J | MemDX™ Membrane Protein Human CXCR3 (C-X-C motif chemokine receptor 3) for Antibody Discovery | E.coli cell-free | Full length | Detergent |
| S01YF-0423-KX468 | MemDX™ Membrane Protein Human CXCR3 (1-53aa) Expressed in HEK293, C-Mouse Fc tag | HEK293 cells | Partial | N/A |
| S01YF-0423-KX49 | MemDX™ Membrane Protein Human CXCR3 (1-53aa) Expressed in HEK293, C-Human Fc tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
A**x: In my experiments, the CXCR3 protein has shown excellent performance. The protein has also demonstrated good stability under various experimental conditions, making it a reliable tool for my studies.
28/Jun/2023
C***y: The technical support provided by Creative Biolabs is top-notch. Their team is highly knowledgeable and responsive.
21/Jan/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Gene Editing
Creative Biolabs offers gene editing services. Investigations have consistently revealed a noteworthy correlation between the augmented expression of CXCR3-B within malignant cellular populations and a discernible influence on their inherent metastatic proclivity. For instance, the deliberate overexpression of CXCR3-B in a cell line has served as a pivotal experimental paradigm, enabling comprehensive scrutiny into its manifold effects on both cellular proliferation and migratory dynamics. This methodological approach, perhaps offering insights into the broader molecular mechanisms at play, facilitates a more nuanced understanding of how this specific receptor isoform might modulate oncogenic processes.
Minicircle Vector Technology
Creative Biolabs offers minicircle vector technology services. A nascent methodological paradigm involves the deployment of minicircle vectors for the genetic encoding of intricate fusion proteins; one notable exemplar comprises the anti-CD25/IL-10/CXCR3 construct. This innovative molecular strategy, characterized by its non-viral nature and purportedly enhanced biosafety profile, has demonstrably yielded therapeutic efficacy within preclinical allograft rejection models. Such interventions, perhaps operating through multifaceted immunoregulatory pathways, appear to confer significant advantages by precisely modulating immune responses, thereby mitigating the deleterious effects associated with transplant rejection. This approach, consequently, warrants further rigorous investigation to fully elucidate its potential in clinical transplantation.
Creative Biolabs offers comprehensive and innovative services to drive the development of CXCR3 cell therapy. Please for more services.
Cytokine Therapy
Creative Biolabs offers cytokine therapy development services. In murine paradigms of pulmonary carcinogenesis, strategic cytokine-based interventions employing specific molecular entities have consistently demonstrated an intrinsic capacity to augment antitumor immune responses. These beneficial outcomes, critically, are predicated upon the indispensable participation of the chemokines CXCL9 and CXCL10, suggesting a concerted interplay within the immune microenvironment. Their presence, perhaps facilitating the robust recruitment and activation of cytotoxic T lymphocytes, appears to be a prerequisite for effective immune-mediated tumor regression. This collective evidence underscores the potential for targeted cytokine therapies to therapeutically manipulate the host immune system against malignant progression.
PD-1 Blockade
Creative Biolabs offers PD-1 blockade development services. In established murine models of both melanoma and colon adenocarcinoma, therapeutic intervention via PD-1 blockade has consistently been observed to elicit a notable alteration in the tumor microenvironment. Specifically, this immunomodulatory strategy demonstrably elevates the intratumoral concentrations of CXCL10. This induced upregulation, consequently, appears to play a pivotal role in augmenting the migratory capacity of T lymphocytes towards the neoplastic foci, thereby enhancing their infiltration into the tumor mass. Furthermore, the sustained presence of elevated CXCL10 levels is also thought to be instrumental in preserving the inherent antitumor activity of these infiltrating T cells.
CXCL10 Fusion Proteins
Creative Biolabs offers CXCL10 fusion protein services. Investigations have revealed a promising therapeutic strategy involving the strategic deployment of CXCL10 fusion proteins, exemplified by constructs in conjunction with glioma-specific cytotoxic T lymphocytes (CTLs). This synergistic approach has demonstrably inhibited tumor progression within relevant experimental models. The underlying mechanism, critically, appears to involve an enhanced chemotactic attraction of both CD8+ T lymphocytes and CXCR3+ T cells towards the neoplastic foci. This targeted recruitment, perhaps a key determinant in overcoming the inherent immunosuppressive nature of the glioma microenvironment, ultimately facilitates a more robust and effective anti-tumor immune response, thereby contributing to the observed reduction in tumor growth.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
