Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-X-C motif chemokine receptor 5 |
| Gene Name | CXCR5 |
| Uniprot | P32302 (Human); Q04683 (Mouse) |
| Synonym | BLR1; CD185; MDR15; C-X-C chemokine receptor type 5; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; CXC-R5; CXCR-5; MDR-15; chemokine (C-X-C motif) receptor 5; monocyte-derived receptor 15 |
| Background | CXCR5 is a G protein-coupled receptor in the CXC chemokine receptor family, encoded by CXCR5 gene. It is one of seven CXC chemokine receptors (CXCR1-CXCR7) in mammals. The receptors can recognize CXC chemokine that possesses an E-L-R amino acid motif. CXCR5 is specifically expressed in mature B-cell and Burkitt's lymphoma. Recently, most studies focus on the role of CXCR5 in the pathological process of cancer. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX444 | NativeExtract™ Human CXCR5 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0223-KX1 | MemDX™ Recombinant Human CXCR5 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MP1347J | MemDX™ Membrane Protein Human CXCR5 (C-X-C motif chemokine receptor 5) for Antibody Discovery | E.coli cell-free | Full length | Detergent |
| MP0282X | MemDX™ Membrane Protein Human CXCR5 (C-X-C motif chemokine receptor 5) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0281X | MemDX™ Membrane Protein Human CXCR5 (C-X-C motif chemokine receptor 5) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
L***s: I recently purchased the CXCR5 protein from Creative Biolabs, and I must say that I am thoroughly impressed with the product and the overall experience.
21/May/2023
M***n: The protein has demonstrated excellent stability under various experimental conditions, making it a reliable and robust tool for my studies.
17/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
T-Regulatory Cells (Tregs) Modification
Creative Biolabs offers Tregs modification services. A sophisticated immunomodulatory strategy centers on the precise genetic manipulation of FOXP3+ regulatory T cells through retroviral transduction, enabling the ectopic expression of the CXCR5 gene. This methodological approach has demonstrably conferred stable and functionally active CXCR5 molecules upon the cellular surface of these critical immune regulatory populations. The resultant surface expression, consequently, permits these engineered Tregs to efficiently traffic towards and infiltrate lymph nodes. This enhanced migratory capacity has been observed to effectively inhibit antibody responses. This strategic engineering thus offers a compelling avenue for precisely modulating humoral immunity and could have significant implications for therapeutic interventions in conditions characterized by aberrant antibody production.
Creative Biolabs offers comprehensive and innovative services to drive the development of CXCR5 cell therapy. Please for more services.
CAR-T Cell Engineering
Creative Biolabs offers CAR-T cell engineering services. In the realm of advanced cellular immunotherapies, the strategic modification of T lymphocytes has emerged as a pivotal approach. Specifically, these immune cells can be genetically re-engineered to concurrently express both a chimeric antigen receptor (CAR) and CXCR5. The integration of CXCR5 ostensibly facilitates the directed extravasation and subsequent homing of these modified CAR-T cells towards malignant lesions, particularly within non-small cell lung cancer (NSCLC) tumors that are characterized by the robust production of CXCL13, the cognate ligand for CXCR5. This targeted migratory enhancement, in turn, is hypothesized to substantially ameliorate the incidence of undesirable off-tumor, on-target toxicities, thereby potentially refining the therapeutic index of such cellular interventions.
Cell Migration and Tumor Targeting
Creative Biolabs offers cell migration and tumor targeting development services. The strategic exploitation of chemotaxis presents a compelling avenue for directing T-cell migration precisely to the tumor microenvironment. This biological phenomenon, which involves cellular movement in response to chemical gradients, offers a sophisticated mechanism to enhance the therapeutic efficacy of engineered T cells. Leveraging analogous chemokine-receptor interactions, can certainly be extended to the CXCR5. Here, the judicious expression of CXCR5 on T lymphocytes could potentially facilitate their guided transmigration. This mechanism would direct them toward neoplastic tissues that are characterized by a pronounced secretion of CXCL13, the specific ligand for CXCR5. Such an approach might thus refine the spatial distribution of therapeutic T cells within complex tumor architectures, potentially leading to more effective disease control.
In Vivo and In Vitro Assays
Creative Biolabs offers in vivo and in vitro assays services. To rigorously substantiate the augmented infiltration of T cells into neoplasms expressing CXCL13, and thereby confirm the enhanced therapeutic efficacy of CXCR5-modified cellular constructs, a multifaceted experimental approach is warranted. This validation typically commences with in vitro assays, which perhaps serve as an initial platform for assessing cellular migratory responses in a controlled environment.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
