Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-X-C motif chemokine receptor 6 |
| Gene Name | CXCR6 |
| Uniprot | O00574 (Human); Q9EQ16 (Mouse) |
| Synonym | BONZO; CD186; CDw186; STRL33; TYMSTR; C-X-C chemokine receptor type 6; G protein-coupled receptor; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; chemokine (C-X-C motif) receptor 6 |
| Background | CXCR6 is a G protein-coupled receptor in the CXC chemokine receptor family, encoded by CXCR6 gene. It is one of seven CXC chemokine receptors (CXCR1-CXCR7) in mammals. The receptors can recognize CXC chemokine that possesses an E-L-R amino acid motif. CXCR6 is specifically expressed in multiple human tissues, such as lymph node, spleen. Recently, most studies focus on the role of CXCR6 in the pathological process of cancer. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX372 | NativeExtract™ Human CXCR6 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MP1348J | MemDX™ Membrane Protein Human CXCR6 (C-X-C motif chemokine receptor 6) for Antibody Discovery | E.coli cell-free | Full length | Detergent |
| MP0284X | MemDX™ Membrane Protein Human CXCR6 (C-X-C motif chemokine receptor 6) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0283X | MemDX™ Membrane Protein Human CXCR6 (C-X-C motif chemokine receptor 6) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
R***y: I recently purchased the recombinant protein from Creative Biolabs for my research project. I must say that I am extremely satisfied with the quality and performance of this product.
07/Apr/2023
J***e: The detailed technical data and documentation provided by Creative Biolabs were very helpful in optimizing my experimental conditions. Their customer support was also top-notch, promptly addressing any questions I had.
21/Aug/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Promoter Analysis
Creative Biolabs offers promoter analysis services. To elucidate the intricate transcriptional regulation of gene expression, a meticulous examination of the promoter region is indispensable. This crucial genomic segment harbors specific sequences, often referred to as transcription factor binding sites, which orchestrate the initiation of gene transcription. A detailed analysis of these sites is therefore a foundational step in understanding gene regulatory networks.
Chromatin Immunoprecipitation (ChIP)
Creative Biolabs offers ChIP services. To quantitatively assess the binding efficiency of specific transcription factors to defined promoter regions, a sophisticated molecular technique known as ChIP is frequently employed. This method provides a powerful means to investigate in vivo protein-DNA interactions. The procedure typically commences with mesenchymal stem cells (MSCs) that have been strategically transfected with vectors designed to overexpress CXCR6, a modification perhaps intended to explore its potential influence on downstream signaling. Subsequently, these cells are stimulated with C-X-C motif chemokine ligand 16 (CXCL16), which may activate relevant signaling pathways.
Creative Biolabs offers comprehensive and innovative services to drive the development of CXCR6 cell therapy. Please for more services.
CXCR6 Transduction in T Cells
Creative Biolabs offers CXCR6 transduction services for T cell development. The precise spatial targeting of therapeutic immune cells to neoplastic lesions represents a critical challenge in the advancement of adoptive cell therapies. This targeted migratory capacity, in turn, is hypothesized to yield a multifaceted improvement in T-cell anti-tumor function. The augmented expression of CXCR6 facilitates superior T-cell homing to the tumor microenvironment. Moreover, it potentially strengthens their adhesion to the malignant cells, a crucial step for sustained effector function. Consequently, this refined homing and adhesion may ultimately lead to a more effective recognition of the tumor cells by the T lymphocytes. The culmination of these enhanced cellular behaviors is, quite critically, an overall improvement in the efficacy of adoptive cell therapy, potentially translating into more robust and durable anti-tumor responses.
CXCR6 as a Biomarker
Creative Biolabs offers biomarker development services. The identification of reliable biomarkers remains a critical endeavor for optimizing the outcomes of adoptive cell therapies and immune checkpoint blockade strategies. In this context, the expression of CXCR6 on CD8+ T lymphocytes is emerging as a compelling predictive indicator of cellular states conducive to effective anti-tumor immunity. Before the administration of adoptive cell therapy, therefore, the assessment of CXCR6 expression levels on these critical effector cells may offer valuable prognostic insights.
Combination Therapies
Creative Biolabs offers combination therapies development services. The dynamic interplay within the tumor microenvironment presents both challenges and opportunities for developing more effective cancer immunotherapies. In this context, the strategic combination of specific T-cell subsets with immune checkpoint inhibitors represents a promising avenue to augment therapeutic outcomes. Specifically, the integration of CXCR6+ T cells within a treatment regimen, when combined with anti-PD-1 antibodies, appears to yield a synergistic therapeutic benefit.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
