Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCysteinyl leukotriene receptor family is a G protein-coupled receptor family that binds cysteinyl leukotrienes which are produced predominantly by myeloid cells associated with various inflammatory responses. Studies have shown that cysteinyl leukotrienes are the most potent bronchoconstrictors known and also have pro-inflammatory effects, making them important mediators in the pathophysiology of human asthma. Early pharmacologic profiling studies have proved the existence of at least 2 cys-LT receptors in mammalian tissues, namely the type 1 cys-LT receptor and type 2 cys-LT receptor. The type 1 cys-LT receptor is a high-affinity receptor for LTD4 and the target of antagonists that are used for the management of asthma. Human CysLT1R mRNA is expressed in bronchial smooth muscle and substantially in myeloid cells, such as macrophages and mast cells. While the human CysLT2R is 38% identical to CysLT1R in amino acid sequence and it binds LTC4 and LTD4 with equal affinity. Furthermore, CysLT2R is expressed both on cells that also express CysLT1R as well as endothelial cells, cardiac Purkinje cells, adrenal medulla, and brain.
Here, we have listed all the members of the Cys-LT receptor family, including cysteinyl leukotriene receptor 1 and cysteinyl leukotriene receptor 2. To learn more information about CysLT1R and CysLT2R, please click the links below.
Aided by our advanced MemDX™ membrane protein production platform, Creative Biolabs is confident in offering diverse target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
