Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Dopamine receptor D1 |
| Gene Name | DRD1 |
| Uniprot | P21728 (Human); Q61616 (Mouse) |
| Synonym | DADR; DRD1A; D(1A) dopamine receptor; dopamine D1 receptor |
| Background | DRD1, a subtype of the dopamine receptor, is the most primary dopamine receptor present in the central nervous system. The D1 receptor family is composed of D1 and D5 subtype. DRD1 is a member of G-protein coupled receptor and Gs/a coupled that indirectly activates cyclic AMP-dependent protein kinase, stimulating the neuron. Due to a high degree of structural homology, both DRD1 and another dopamine receptor D5 bind similar drugs. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX284 | NativeExtract™ Human DRD1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX4064K | MemDX™ Membrane Protein Human DRD1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0307X | MemDX™ Membrane Protein Human DRD1 (Dopamine receptor D1) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MPX4159K | MemDX™ Membrane Protein Human DRD1 Expressed in E.coli with 6xHis tag at the N-terminus, Partial (338-446aa) | E.coli | Partial | N/A |
| Please for more products or customization | ||||
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We provide tailored solutions to meet your specific requirements. Please for more services.
Genotyping and Genetic Variation Analysis
Creative Biolabs offers genotyping and genetic variation analysis services. The elucidation of genetic variations intrinsically linked to the DRD1 locus necessitates a robust genotyping methodology. Among the panoply of molecular techniques routinely employed for this purpose, Restriction Fragment Length Polymorphism (RFLP) frequently serves as a foundational approach for discerning specific allelic differences. For instance, the operational principle of RFLP hinges upon the judicious application of bacterial restriction endonucleases; these enzymes meticulously cleave DNA at highly specific recognition sequences, thereby facilitating the identification of sequence polymorphisms. This analytical paradigm, in turn, offers a powerful means by which to stratify cohorts, perhaps enabling the preliminary identification of individuals who may exhibit divergent therapeutic responses to DRD1-targeted pharmacological interventions. Such genomic insights are, indeed, pivotal for the advancement of personalized medicine.
Gene Expression Analysis
Creative Biolabs offers gene expression analysis services. Interrogation of transcriptional profiles serves to elucidate the intricate mechanisms by which DRD1 expression is modulated across varied physiological or experimental states. For instance, publicly accessible repositories of genomic information, such as the NCBI Gene Expression Omnibus (GEO), have been extensively leveraged for comparative analyses. These datasets facilitate the discernment of differential gene expression, notably exemplified in studies contrasting euthymic and experimentally perturbed rodent models. This analytical paradigm, consequently, may facilitate the identification of putative pharmacological targets. Specifically, it enables the precise ascertainment of genetic loci exhibiting altered transcriptional kinetics subsequent to the pharmacological agonism or antagonism of DRD1, thereby offering critical insights for therapeutic development.
Creative Biolabs offers comprehensive and innovative services to drive the development of DRD1 cell therapy. Please for more services.
Cell-Specific Viral Vectors
Creative Biolabs offers cell-specific viral vectors development services. The ongoing advancement in cell-type-specific viral delivery systems, notably encompassing adeno-associated virus (AAV) vectors, permits the precise transduction of therapeutic genetic cargo into DRD1-positive cellular populations. Empirical evidence derived from preclinical models of Parkinson's pathology, spanning both murine and non-human primate paradigms, unequivocally indicates that such methodologies have demonstrated considerable efficacy in ameliorating parkinsonian motor deficits. Consequently, the deployment of these sophisticated vectors affords unparalleled control over the targeted manipulation of DRD1-expressing cells.
Immunofluorescence and Imaging Techniques
Creative Biolabs offers immunofluorescence and imaging techniques development services. The discernment of DRD1 expression patterns and its subcellular localization within cellular constructs and complex tissue architectures critically relies upon immunofluorescent methodologies and sophisticated microscopic imaging modalities. This approach thereby yields critical insights into its precise topographical arrangement and specific cellular microenvironment. Furthermore, the application of cutting-edge optical microscopy techniques considerably augments both the spatial fidelity and intricate structural elucidation obtained from these investigations. These advancements, crucially, empower investigators to achieve a more profound comprehension of DRD1's functional significance within fundamental cellular processes and its mechanistic contributions to diverse disease states.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
