Introduction of DRD4
DRD4, encoded by the DRD4 gene, is a dopamine D2-like G protein-coupled receptor. A recent report has shown that the structure of DRD4 was in complex with the antipsychotic drug nemonapride. Similar to other dopamine receptor subtypes, the D4 receptor is activated by the neurotransmitter dopamine. Many research have shown that DRD4 was related to many neurological and psychiatric conditions, including schizophrenia and bipolar disorder, attention deficit hyperactivity disorder (ADHD), addictive behaviors, Parkinson's disease, and eating disorders.
|Basic Information of DRD4|
|Protein Name||D(4) dopamine receptor|
|Organism||Homo sapiens (Human)|
Function of DRD4 Membrane Protein
Dopamine receptors control neural signals that modulate behavior. The D4 receptor is considered to be D2-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP. Associations were found with ADHD, substance dependences, several specific personality traits, and reaction to stress. These findings have implications for pharmacogenetics. DRD4 has an influence on the postsynaptic action of dopamine and is implicated in many neurological processes, exhibits polymorphism and is one of the most studied genes in connection with psychiatric disorders. As a target for drugs, DRD4 has been applied, which play a role in treating schizophrenia and Parkinson disease.
Fig.1 Structure of DRD4 membrane protein.
Application of DRD4 Membrane Protein in Literature
This article reports that the selective overexpression of DRD4 at the neuronal level reduced 3-NP-induced neurodegeneration, which suggests an important function of the neuronal DRD4 in the modulation of neurodegeneration.
This article reveals that provide insight into the regulatory role of the D(4) receptor on AT(1a) receptor expression and function in VSMCs and suggest that targeting the action of the D(4) receptor may represent an effective therapeutic approach for the treatment of cardiovascular diseases.
This article shows that the dopamine D(4) receptor is an interesting receptor since it has a polymorphic region in its third intracellular loop, resulting in receptor isoforms of varying length and amino acid composition.
This article reviews the principle published associations of DRD4 variants with psychiatric disorders.
DRD4 Preparation Options
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