How do you validate the antibodies you use for Western blotting and IHC?

The antibodies we use in our ADAMTS20 analysis are rigorously validated in-house to ensure high specificity and sensitivity. Each antibody undergoes a series of validation steps, including Western blotting with recombinant protein, positive and negative cell line screening, and immunohistochemical staining on a range of human tissues.

Can you help with the interpretation of the results from the ADAMTS20 mutation analysis?

We provide comprehensive reports for our ADAMTS20 mutation analysis services. The reports include detailed information on identified mutations, their predicted functional impact, and relevant literature references, with our scientific team available to help you interpret the findings.

Do you provide controls for your ADAMTS20 analysis services?

We always include appropriate positive and negative controls in our ADAMTS20 analysis services to ensure the reliability and reproducibility of the data. For example, for Western blotting, we use a recombinant ADAMTS20 protein as a positive control.

What methods do you use for your protein-protein interaction analysis?

Our protein-protein interaction analysis for ADAMTS20 uses a combination of advanced techniques. We employ a mix of computational prediction using state-of-the-art bioinformatics tools and experimental validation methods such as co-immunoprecipitation and mass spectrometry to map the interaction network.

Can I use my own samples for the ADAMTS20 analysis services?

Yes, you are welcome to provide your own samples for our ADAMTS20 analysis services. Our team will perform a quality check upon receipt to ensure the samples meet the necessary requirements for the planned analysis, and we will advise you on any potential issues.

How do you ensure the confidentiality of my research data?

We take the confidentiality of all client research data very seriously. All projects are handled with the utmost discretion and are governed by strict confidentiality agreements. Your data is stored securely and is only accessible to the authorized scientific personnel working on your ADAMTS20 analysis project.

ADAMTS20 Analysis Service - Creative Biolabs

Creative Biolabs provides a comprehensive suite of ADAMTS20 analysis services designed to accelerate your research. Our offerings can function as standalone solutions or integrate seamlessly into a complete, end-to-end preclinical program, providing the precise data you need to drive meaningful discovery and development.

Introduction of ADAMTS20

ADAMTS20 is a key member of the ADAMTS family of secreted proteinases, which share the metalloproteinase domain with matrix metalloproteinases (MMPs). This unique enzyme is an ortholog of the nematode protease Gon-1, essential for gonadogenesis, and plays a fundamental role in tissue remodeling and development. Its dysregulation has been linked to a number of pathological conditions, including cervical large cell neuroendocrine and carcinoma Peters-Plus syndrome. The gene is annotated for its metalloendopeptidase and endopeptidase activities.

Studies indicate that ADAMTS20 is overexpressed in various human malignancies, including brain and breast carcinomas, suggesting its direct involvement in tumor progression. The expression of ADAMTS20 by cancerous cells may be the result of complex cross-talk between the cancer cells and their surrounding stroma.

ADAMTS20 Analysis Services at Creative Biolabs

Creative Biolabs offers a robust and versatile platform for ADAMTS20 analysis, tailored to meet your specific research needs with comprehensive gene and protein expression services. Our expertise spans a full range of methodologies, and we provide highly specific antibodies for a wide array of scientific applications, including Western blotting, IHC, and ICC. Our services include, but are not limited to:

We use advanced techniques like RT-PCR and ISH to quantify gene expression levels with exceptional sensitivity and accuracy.

Our methods, including highly sensitive ELISA and Western blotting, allow for precise quantification of the ADAMTS20 protein.

We provide expert prediction analysis of ADAMTS20 gene and protein interactions, mapping its functional network.

We offer the development of specialized ADAMTS20-deficient animal models for sophisticated in vivo studies.

Our comprehensive genetic analysis services include detailed ADAMTS20 mutation analysis to identify and characterize variants.

Service Workflow

Our streamlined service workflow is designed for efficiency and clarity, with each step carefully managed to ensure the highest quality of service.

01Initial Consultation

We begin with a detailed, one-on-one consultation to fully understand your specific research goals, allowing us to collaboratively design a tailored project plan for ADAMTS20 analysis.

02Sample Submission

Following the consultation, you will provide us with your starting materials. We are equipped to handle a wide range of biological samples, including cell lysates, fresh tissue sections, or purified proteins, all of which are handled with care.

03Expert Analysis

Our team of expert biologists then performs the analysis using state-of-the-art technologies. We adhere to rigorous quality control standards at every stage, guaranteeing that the data is both reliable and reproducible.

04Final Delivery

We deliver a comprehensive scientific report. This final document includes all raw data, a detailed interpretation of the findings, and an executive summary to provide clear, actionable insights from your ADAMTS20 analysis.

Applications

Oncology Research

The well-documented overexpression of ADAMTS20 in various carcinomas makes its analysis a crucial tool for understanding tumor progression and metastasis. This provides key insights for identifying novel therapeutic targets and developing personalized cancer treatments.

Developmental Biology

Studying the role of ADAMTS20 in tissue remodeling and its association with developmental disorders, such as the belted phenotype in mice, provides fundamental insights into intricate biological pathways. Analyzing its expression helps elucidate mechanisms behind congenital defects and cellular differentiation.

Preclinical Drug Development

Analyzing ADAMTS20 activity and expression in response to novel drug candidates is essential for evaluating their efficacy and mechanism of action. This analysis helps to validate potential inhibitors or modulators of this important metalloprotease.

Biomarker Discovery

As a key secreted metalloprotease, ADAMTS20 can serve as a valuable biomarker for disease diagnosis, prognosis, and monitoring, particularly in the context of cancer and extracellular matrix-related disorders. Its presence and levels can indicate disease state or progression.

Service Highlights

FAQs

Increase your chance for new discoveries and let us analyze your sample. Creative Biolabs just needs a single run and less volume sample in any matrix. Receive reliable and reproducible data in a confidential scientific report. If you cannot find the service you're looking for, contact us today to develop custom solution for specific needs.