Secreted aldo-keto reductase family 1-member B10 (AKR1B10) has been identified in the blood as a cancer marker. Creative Biolabs offers quantitative AKR1B10 biomarker profiling services on our high-throughput platforms. We have extensive experience exploring a robust range of biomarkers and the expertise to provide you with a right-fit biomarker solution. Our analysis services are highly customized, which allows you to benefit from affordable prices and fast delivery time.
Background
AKR1B10 is a secretory protein that interferes with cell survival by modulating lipid synthesis, mitochondrial function, and oxidative status. AKR1B10 may promote carcinogenesis through the conversion of highly reactive aldehyde and ketone groups into hydroxyl groups. Overexpression of AKR1B10 is an initial event in the carcinogenesis of various human malignancies, including non-small cell lung carcinoma (NSCLC), pancreatic cancer (PC), breast cancer, oral squamous cell carcinoma (OSCC), nasopharyngeal carcinoma (NPC) and hepatocellular carcinoma (HCC).
Fig.1 Structure of AKR1B10.Distributed under CC BY-SA 3.0, from Wiki,
without modification.
Bioinformatic and structural analyses proved that in the AKR1B10 primary structure Cys299 represents the Cys298 homolog of AKR1B1 which may play a significant role in carbonyl reducing activity of AKR1B10. Due to this conserved Cys299 residue, AKR1B10 may be equivalently inhibited by fibrates.
We Have Your Biomarker Assay Needs Covered
Based on its overexpression in neoplastic cells, AKR1B10 is considered a tumor marker that can be detected in situ and the blood. Creative Biolabs provides classical enzyme-linked immunosorbent assays (ELISAs), electrochemiluminescence (ELC) assays, and immunohistochemistry assays for our clients. Moreover, it is also essential to develop a new, simple, and rapid yet highly sensitive and specific method for the detection of AKR1B10 in serum.
Creative Biolabs has been committed to rapid in vitro diagnosis of protein biomarkers and has invested a lot of energy in quantum dots (QDs) based assay development. Semiconducting QDs are suitable for photoelectrochemical tumor marker detection, especially in complex biological samples. We provide customized QD-based assay development for AKR1B10 detection use.
Our major services include but not limited to the following:
- ELISA/IHC/WB/ELC
- Enzyme kinetic assay of Cys 299 in AKR1B10
- AKR1B10 inhibitor screening
- shRNA knockdown
- QD-based assay development
Biomarkers are increasingly important in pharmaceutical development and have a wide range of potential clinical utilities. Is early phase decision making as indicator of safety and efficacy? Creative Biolabs offers biomarker analysis services and has a wealth of experience in the detection and quantitation of biomarkers in a wide variety of matrices.
If you cannot find the service you're looking for, contact us today to develop custom solution for specific needs.
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