As a nimble biomarker CRO, Creative Biolabs offers singleplex, multiplex assays, and commercially available assays/kits to support your biomarker projects. All our solutions undergo a fit for purpose biomarker validation. Creative Biolabs maintains high-quality standards to offer you comprehensive arachidonate 5-lipoxygenase (ALOX5) analysis services.
Background
ALOX5 is a non-heme iron-containing dioxygenase that encodes lipoxygenase and metabolizes AA into hydroperoxyderivatives (5-HPETE) and further into 5-hydroxyeicosatetraenoic acid (5-HETE), conferring invasion, growth, and chemopreventive advantage in cancer cells. ALOX5 mediates lipid peroxidation by producing lipid peroxides. Serum ALOX5 is elevated in breast cancer, and gastrointestinal cancer and serves as a promising therapeutic target. The high ALOX5 expression also serves as an independent prognostic predictor of poor prognosis in low-grade glioma (LGG).
Fig.1 ALOX5-associated pathways potentially contributing to LGG pathogenesis.1
Analysis Services at Creative Biolabs
Our biomarker analysis services begin by examining the target, selecting an appropriate analysis platform, and surveying or developing materials such as proteins, matched antibody pairs, kits, and controls. Creative Biolabs performs pre-validation testing of biomarker assays using calibration standards and quality controls to replicate the analysis of provided samples. Once initial assay development is complete, our team of expert scientists conducts appropriate validation of each of your biomarker services to demonstrate methodological reliability for the intended use.
Using simple and well-established platforms, researchers can explore significant unmet needs in life science research using digital biomarker analysis technology. Creative Biolabs also provides the option of developing multiplex assays to minimize the sample volume.
Our popular analysis services targeting ALOX5 include but are not limited to the following:
| Cat | Service |
| BAS96-1 | ALOX5 Expression Analysis |
| BAS96-2 | ALOX5 Methylation Analysis |
| BAS96-3 | ALOX5 Knockdown Analysis |
| BAS96-4 | Immune Cell Infiltration Analysis |
| BAS96-5 | ALOX5 Promoter Interaction Analysis |
| BAS96-6 | Drug Sensitivity Analysis |
| BAS96-7 | ALOX5 Polymorphisms Analysis |
Creative Biolabs holds extensive expertise in a wide range of biomarker assay development and validation services to meet your needs. If you are interested in our services, please don't hesitate to contact us to develop custom solutions for specific needs. We will work to accommodate your request.
Reference
- Pan, Rui-han, et al. "Arachidonate lipoxygenases 5 is a novel prognostic biomarker and correlates with high tumor immune infiltration in low-grade glioma." Frontiers in Genetics 14 (2023): 1027690. Distributed under CC BY-SA 4.0, without modification.
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