Creative Biolabs is a leading service provider that focuses on IVD (in vitro diagnostics) antibody development. Based on our extensive experience and advanced platform, now we are able to provide the antibody pairs development services for our customers all over the world. Our multifarious services can be tailor-designed to meet your specific needs.

Introduction of Antibody Pairs

Antibody pairs are two different antibodies generated against different epitopes or binding regions, but with the same target. This unique property allows the simultaneous binding to the same target against two different epitopes, which present great potential in biological research. Creative Biolabs now can develop the most suitable matched antibody pairs for our customers.

Antibody pairs.Fig.1 Antibody pairs.

Applications of Antibody Pairs

An antibody pair always includes a capture antibody and a detection antibody which are the basis of many biological experiments, including but not limited to sandwich ELISA, IP-WB, and protein-protein interaction. The available antibody pairing formats can be two monoclonals (mAb/mAb), two polyclonals (pAb/pAb), or a combination (mAb/pAb) of both. It is worth noting that each antibody type offers distinct advantages, so it is necessary to appreciate the difference and how to use them in different conditions. Monoclonal antibodies can be spread used in all types of ELISAs and also work with polyclonal antibody to improve the chance of capturing antigen from a complex solution. Polyclonal antibodies present all the available epitopes in any given antigen but must be tested and validated thoroughly.

Applications of antibody pairs.Fig.2 Applications of antibody pairs.

Moreover, the research of pharmacokinetics and pharmacodynamics in the field of the drug development is also dependent upon antibody pairs to some extent.

Antibody Pairs Screening

In order to avoid the time-consuming stage of antibody pair identification in sandwich ELISA, Creative Biolabs has developed the bead-based method for antibody pairs screening. The standard protocol can be divided into three main steps:

  • Antibodies selection
  • Antibodies conjugation with beads
  • Data collection and analysis

Moreover, we can also provide abundant matched antibody pairs to free up your time in searching and testing the appropriate capture and detection antibodies.

In addition to the IVD antibody pairs development, Creative Biolabs provides other services related to IVD antibody development which including monoclonal antibody development, polyclonal antibody development, and recombinant antibody development. With our well-established platform, the experienced scientists here at Creative Biolabs is dedicated to helping you with your special projects. If you are interested in our services, please do not hesitate to contact us for more details.

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