To meet more diagnostic assay needs and make diagnosis more convenient and intuitive, a series of biological conjugations are applied, such as fluorescence labeling, protein particle conjugation, antibody oligonucleotide conjugation, etc. As a pioneer company in in vitro diagnostics (IVD) antibody development, Creative Biolabs offers a full range of conjugation services, either as part of an IVD project development or as a standalone service, to meet our global client's specific requirements. With years of experience, our professional scientists provide custom conjugation of numerous labeled materials, such as HRP, biotin, or a fluorophore, either to an antibody in our catalog or as a stand-alone service for customer-supplied material.
Conventional conjugation usually refers to labeling a monoclonal antibody or polyclonal antibody with fluorescence dyes through chemical or non-chemical conjugation. With the technology development, more and more antibodies or proteins can be conjugated with various biologically active molecules, such as oligonucleotides and their analogs, peptides, proteins, or with any molecular group that adds valuable properties, including radionuclides, enzymes, toxins, metal chelates, haptens, fluorophores, and others.
Fig.1 Antibody conjugates with different materials.1
The conjugation services we can offer include but are not limited to:
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Various protein conjugations have been developed, such as glycoproteins, chromoproteins, enzyme-linked proteins, nucleoproteins, etc., for different in vitro diagnostic immunoassays and immunotherapy development. Creative Biolabs provides high-quality protein conjugation services for various biological applications with numerous materials. |
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Different kinds of multifunctional particles have been developed for various biological applications, such as biomolecule separation, cellular and molecular detection, drug delivery, etc. Creative Biolabs provides a number of particle conjugation services for molecular imaging, target identification, targeted drug delivery, and other related IVD applications. |
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Biotin-labeled antibodies, proteins, and nucleic acids have been widely used in numerous detection systems especially when the target of interest is expressed at low levels and cannot be detected easily. Experienced scientists at Creative Biolabs offer a full range of custom biotin labeling services without altering the bioactivity of target molecules. |
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Fluorescent dye labeling makes in vitro diagnostic immunoassays more convenient and intuitive. Creative Biolabs can conjugate your antibody or protein to numerous fluorescent dyes for the analysis of protein interactions, enzyme activity, conformational changes, protein localization, etc. Moreover, multiple fluorescence labeling is also within our capabilities. |
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Oligonucleotide conjugations, including oligonucleotide-antibody, oligonucleotide-protein, and oligonucleotide-oligonucleotide, have been developed past few years in numerous applications from diagnostics to therapeutics. Added by state-of-the-art platforms, Creative Biolabs provides oligonucleotide conjugation services as a sensitive method for different IVD applications. |
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Electrochemiluminescent materials, especially Europium and Ruthenium, have also been applied for IVD immunoassays. These special conjugations have a longer fluorescence lifetime and perform well in temporal and spatial control. Creative Biolabs here also provides tailored special labeling services based on rich experience in bioconjugations. |
As a pioneer company in IVD antibody development, Creative Biolabs is dedicated to offering different kinds of conjugation services to global customers for IVD immunoassays. Our dazzling array of conjugation services can be performed in-house as an extension of our antibody development services or as a stand-alone service. Don't hesitate to contact us, and discuss with our technical support about your conjugation needs.
Reference
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