Natural mutations in the ASXL2 gene are associated with breast, bladder, pancreatic, ovarian, prostate, and blood cancers. It also plays important roles in neurodevelopment, heart function, lipogenesis, and osteoclast formation. Creative Biolabs provides one-stop ASXL2 analysis services based on various test platforms.
ASXL2 Function
ASXL2 is an ETP family protein that interacts with PPARγ and regulates glucose homeostasis, lipogenesis, and osteoclast differentiation through activation of PPARg.
Fig.1 ASXLs protein family.1
- ASXL2 deficiency inhibits osteoclast formation and impairs osteoclast formation in a cellular autonomic manner.
- ASXL2 is highly expressed in osteoblasts.
- ASXL2 deficiency promotes insulin resistance and glucose intolerance.
- ASXL2 deficiency leads to abnormal absorption cells and leads to lipid storage failure, increased circulating triglycerides and cholesterol.
ASXL2 Mutations
The mutation sites of ASXL2 mutation were mainly located in exons 11 and 12, the ASXL2 mutation results in loss of expression of ASXL2 protein and is the most common mutation in patients with acute myeloid leukemia with RUNX1-ETO translocations.
ASXL2 mutations are common in children and adults with acute myeloid leukemia (AML), and ASXL2 mutations are found in AML patients with t (8; 21) translocation is common and associated with an increased risk of recurrence. The accumulation of ASXL2 mutation status reduced RUNX1-RUNX1T1 transcripts throughout the course of treatment in adult patients, and the recurrence rate of AML patients with t (8; 21) increased to 36%.
Services Provided by Creative Biolabs
Recent studies on ASXL2 mainly focus on the pathogenesis of ASXL2 mutation or deletion, or the complex-formation mechanism and function of ASXL2 protein. Our services can be customized to suit the specific needs of our clients, popular analysis services targeting ASXL2 include but not limited to the following:
| Cat | Service |
|---|---|
| BAS116-1 | ASXL2 Antibody Development |
| BAS116-2 | ASXL2 Protein Expression |
| BAS116-3 | ASXL2 Western Blotting Assay |
| BAS116-4 | ASXL2 Immunohistochemistry Assay |
| BAS116-5 | ASXL2 Protein Complex Analysis |
| BAS116-6 | ASXL2 Chromatin Immunoprecipitation Assay |
| Cat | Service |
|---|---|
| BAS116-7 | ASXL2 PCR Assay |
| BAS116-8 | ASXL2 Sequence Assay |
| BAS116-9 | ASXL2 Phenotypic Analysis |
| BAS116-10 | ASXL2 Mutation Analysis |
| BAS116-11 | ASXL2 ChIP Sequencing Assay |
| Cat | Service |
|---|---|
| BAS116-12 | ASXL2-KO Cell Line Construction |
| BAS116-13 | ASXL2 Single-cell Colony Assay |
| BAS116-14 | ASXL2-Deletion Mouse Model Construction |
We are committed to providing the highest quality of custom services and products at the most reasonable prices. Please feel free to contact us for more information and a formal quote.
Reference
- Daou, Salima, et al. "Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1." Nature communications 9.1 (2018): 4385. Distributed under CC BY-SA 4.0, without modification.
For Research Use Only.
