Chemiluminescent Immunoassays (CLIA)

Creative Biolabs is a leading service provider that focuses on IVD development. With our well-established chemiluminescent immunoassays (CLIA) platform, the experienced scientists here are dedicated to providing CLIA-based services to meet your specific demands.

CLIA represents a versatile, ultrasensitive tool with a wide range of applications in biotechnology among assay methods. CLIA is an assay that combines a chemiluminescent system with immunoreaction to determine the concentration of samples according to the intensity of the luminescence that the chemical reaction emits. Some reagents have been used as CLIA labels, and upon the introduction of the CIAL substrates, the system produces chemiluminescence so that the samples can be detected quantitatively. Our CLIA platform provides the most popular CLIA substrates such as luminol, isoluminol, and their derivatives, acridinium ester derivative, peroxidase, and alkaline phosphatase (ALP). Moreover, we also provide the most used labeling enzymes such as horseradish peroxidase (HRP) and ALP to meet our customers' requirements.

  • Applications of CLIA

CLIA has gained increasing attention in different fields, including life science, clinical diagnosis, environmental monitoring, food safety, bacteria identification, pharmaceutical analysis, and other areas because of its high analysis sensitivity, reasonable specificity, and wide linear range. Currently, CLIA has reached a higher level due to assistance from new nanomaterials (e.g., gold nanoparticles, quantum dots, and magnetic materials) and coupling with other developed technologies (e.g., immunochromatography and Microfluidic chips).

CLIA assay. Fig.1 CLIA assay. (Cinquanta, 2017)

Our Services based on CLIA Platform

In recent years, CLIA has become very popular due to its high sensitivity, wide dynamic range, and complete automation. With long-term expertise in IVD development, Creative Biolabs is your ideal partner based on our CLIA platforms and offers you the best advice and support to advance your programs. Our powerful CLIA platforms include a series of CLIA technologies, including but not limited to direct CLIA, indirect CLIA, electrochemical CLIA, multiplexed CLIA. Based on these powerful CLIA platforms, we are confident in offering high-quality CLIA based kits development to contribute significantly to the success of your projects.

Advantages of our CLIA Platform

  • High sensitivity and specificity
  • Wide dynamic range
  • Absence of interfering emissions (i.e., high specificity)
  • Rapid acquisition of the analytical signal
  • High stability of reagents and their conjugates
  • Low consumption of reagents

With the development of science and technology, CLIA will enjoy more extensive applications and faster growth, coupled with focused research efforts. Over the years, Creative Biolabs has been accumulated further experience in IVD development based on our advanced CLIA platforms for our customers worldwide. If you would like to know more about our CLIA services, please get in touch.


  1. Cinquanta, L.; et al. Chemiluminescent immunoassay technology: what does it change in autoantibody detection?. Autoimmunity Highlights. 2017, 8(1), p.9.

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