Digital technologies can improve each stage of the diagnostic process, from accessioning of specimens and progress through the grossing/cut-up room to efficient viewing and software for annotation and report creation, and the ability to share slides inter- and intra- departmentally. Digital pathology offers the potential for improvements in quality, efficiency, and safety that are compelling reasons for widespread implementation. Committed to in vitro diagnostics (IVD) development over years, Creative Biolabs has accumulated rich precious experience in practice. We are capable of providing comprehensive detection methods including high-quality digital pathology analysis services.

Introduction of Digital Pathology

Advances in molecular biology are transforming image-based specialties like pathology from primarily subjective-based analyses to quantitative-based digital analyses. The technologies used to capture high-resolution images, create digital versions of glass slides, and make virtual microscopy possible, as well as advance machine-based learning, have paved the way for the digital era of pathology. Digital pathology has the potential to fundamentally change the way that histopathology is practiced by streamlining the workflow, increasing efficiency, improving diagnostic accuracy, and facilitating the platform for the implementation of artificial intelligence-based computer-assisted diagnostics.

In a digitized surgical pathology department, sections on glass slides are stained and scanned as they become available.Fig.1 In a "digitized" surgical pathology department, sections on glass slides are stained and scanned as they become available. (Taylor, 2014)

Examples of Digital Pathology Analysis Methods in Medicine

  • Image analysis

Image analysis has long been promised as a way to remove the subjectivity and variability in pathology diagnosis. A fully digital workflow would mean that image analysis could be performed on any pathology image without the need for specific image preparation. Image analysis software is already widely available and has Food and Drug Administration (FDA) regulatory approval in the United States for the quantification of nuclear markers such as estrogen receptor or cell membrane markers such as HER2/neu.

Urothelial carcinoma tissue core stained via an immunofluorescence assay.Fig.2 Urothelial carcinoma tissue core stained via
an immunofluorescence assay. (Saeed-Vafa, 2015)
  • AQUA

AQUA is based on key features of fluorescent immunohistochemistry (IHC). It analyzes digital images captured from slides stained with the typical immunofluorescence protocol in which an unlabeled primary antibody targets a molecule and then a secondary antibody coupled to a fluorophore (a fluorescent chemical compound that can re-emit light if it exists) recognizes and binds to the primary antibody. Using different antibodies and fluorophores, different compartments and targets can be specifically marked. AQUA scores are reproducible and provide continuous variable data that can be used to define superior marker classifiers and improve the prognostic and predictive performance of in situ-based tissue biomarkers.

  • Tissue Studio

Tissue Studio is an image analysis environment that takes a context-based, relational approach, rather than a pixel-based, pattern recognition approach. Its segmentation algorithms begin by grouping pixels into objects called image object primitives. These objects are then merged into what the user recognizes as the microanatomy of the tissue and are then related to the super objects (e.g., white space, lumen, tissue, background, glands). Because of this hierarchical relationship, which links the smallest elements in an image to the largest, Tissue Studio provides a means for detecting and quantifying hundreds of relational attributes of the tissue that could be related to clinical outcomes. Doing so enables pathologists to ask more advanced questions of the underlying biology.

Services at Creative Biolabs

Focusing on IVD development services over years, Creative Biolabs is professional and experienced in this field. Our scope of services covers gene level detection, protein level detection, cell level detection, and tissue level detection. With strong foundations such as advanced facilities, the latest technologies, and Ph.D. level specialists, our services are powerful guaranteed and will give every client top-rated customer experiences.

  • Professional services with a great industrial reputation
  • Flexible service form according to your choice
  • Efficient and high-quality

As a global-leading CRO company, Creative Biolabs aspires to become the best scientific service provider. Every effort we made is to bring our customers better services. If you are interested in digital pathology or any other IVD development services, please don't hesitate to contact us for more information.


  1. Taylor, C. R. Issues in using whole slide imaging for diagnostic pathology: "Routine" stains, immunohistochemistry and predictive markers. Biotech Histochem. 2014, 89(6): 419-23.
  2. Saeed-Vafa, D.; Magliocco, A. M. Practical applications of digital pathology. Cancer Control. 2015, 22(2): 137-41.

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