Electrochemical biosensor is a strong candidate for cancer theranostics owing to their advantage of ultra-sensitivity, high selectivity, low cost, quick readout, and simplicity. They have played a critical role in the transition towards point-of-care (POC) diagnostic devices. Modern electrochemical bio-affinity sensors, such as DNA- or immunosensors, offer remarkable sensitivity essential for early cancer detection. With rich experience in electrochemical biosensor development, Creative Biolabs provides cancer electrochemical biosensing services as well as offer customized sensor products for worldwide customers.

Overview of Cancer Detection

Cancers are normally induced by uncontrollable cell proliferation which is accompanied by a series of cellular events, such as specified genomic alterations, following transcriptome and protein alteration, tumor formation, cancer cell migration, and tumor metastasis. Besides, the tumor related microenvironment also changes. Traditional methods for detecting cancer, such as histopathological diagnostic techniques and immunological methods often request complex operation, long turnaround time and experienced personnel. These assays are difficult to obtain an early diagnosis and prognosis quickly for malignant tumors. Compared with traditional technology, electrochemical technique has the advantages of rapid detection, high sensitivity and specificity in the detection of tumor cells. Electrochemical biosensors provide powerful tools for cancer early diagnosis, which have been successful in differentiating tumor cells from normal cells and targeted detection of localized or circulating tumor cells (CTCs).

Fig.1 Cancer detecting. (Creative Biolabs Authorized)

Advancing Cancer Detection by Creative Biolabs

Sensitive biosensors based on various electrochemical techniques have been widely used in the detection of cancer cells. The use of electrochemical biosensors for cancer detection can be carried out by Creative Biolabs from the following three major aspects.

  • Electrochemical immunosensors for tumor cell detection

Electrochemical immunosensors constructed on the basis of specific reactions between antigens and antibodies, specific recognition function of adapters and the cell impedance principle have successfully achieved high-sensitivity linear detection of various cancer cells.

  • Electrochemical nucleic acid biosensors in tumor cell detection

Electrochemical nucleic acid biosensors use nucleic acid molecules as molecular recognition elements, whose principle is to fix a single strand of oligonucleotides on the electrode and hybridize with the target DNA, and detection of target substances by detecting changes in electrochemical parameters before and after hybridization. In recent years, quantum dots (QDs) and aptamer are usually combined to capture cells.

Electrochemical probes based on QD-aptamers were constructed to detect tumor cells.Fig.1 Electrochemical probes based on QD-aptamers were constructed to detect tumor cells.1, 2

  • Detection of CTCs by electrochemical biosensors

It is necessary to develop highly specific and sensitive tools to capture CTCs which accounts for only 0.004% of the number of cells in the blood. Compared with other biosensors, electrochemical biosensor has higher sensitivity, simplicity and low cost. Different new nanomaterials are being used to modify electrodes to amplify biometric event signals, narrow detection range and improve detection sensitivity. More specific electrochemical probes have been constructed to improve the ability to capture CTCs.

Services

  • Integration of electrochemical biosensor with liquid biopsy
  • Integration of electrochemical biosensor with microfluidic chips
  • Animal level and in vivo detection
  • Various electrochemical measurement methods: amperometry / potentiometry…

New advancements of electrochemical biosensor used in cancer detection have been widely reported recent years. If you are interested in our services, please feel free to contact us for more information.

References

  1. Zhang, Zhenhua, et al. "Application of electrochemical biosensors in tumor cell detection." Thoracic cancer 11.4 (2020): 840-850.
  2. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only.



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