A fundamental question for nervous system formation is how neuronal subtype specification and developmental gene expression are controlled within maturing neurons. The alpha 6 subunit of the γ-aminobutyric acid type A (GABAA) receptor (GABRA6) provides an excellent opportunity to investigate intrinsic transcriptional mechanisms controlling granule neuron subtype-specific gene regulation. Armed with an advanced technology platform and extensive biomarker analysis services, Creative Biolabs offers custom GABRA6 analysis services for global clients.
Biomarker Information
γ-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. The GABAA receptor is the site of action for many important drugs such as barbiturates, benzodiazepines, and ethanol. Among them, the GABRA6 receptor is a potential biomarker for neuronal toxicity.
Fig.1 The structure of GABAA receptor.1
GABRA6 and Disease
A previous study found that the T1521C variant in the GABRA6 gene is related to specific personality characteristics and a significant reduction in the response of hormones and blood pressure to psychological stress. Another study indicated that a GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy (CAE). CAE-associated GABRA6 R46W mutation could cause neuronal disinhibition and thus increase susceptibility to generalized seizures through a reduction of αβγ and αβδ receptor function and expression.
Analysis Services at Creative Biolabs
- GABRA6 single gene sequencing
- GABRA6+ cells separation services
- GABRA6 gene expression research
- GABRA6 ELISA assay
Creative Biolabs also harbors tagged ORF clones, recombinant protein as well as highly specific antibodies directed against human GABRA6. Antibodies can be used in WB, IHC, and live cell imaging applications. We also have extensive experience and expertise in handling various types of custom assay development. Creative Biolabs is competent to integrate existing biology resources and customers' individual needs to provide you with tailored experimental solutions. If you want to order custom analysis services, please feel free to contact us for more information.
Reference
- From Wikipedia: By Swastik.phulera - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/wiki/File:Fig-GABAA_receptor.png
For Research Use Only.
