Creative Biolabs is a world-leading service provider of application-specific antibody development. Here, we introduce our in vitro diagnostic (IVD) antibody development and immunoassay development services targeting the β-trace protein. We are confident that our commitment to science and research will enable us to offer you the best products and services.

β-trace Protein

The β-trace protein, also known as Beta-trace protein (BTP), is a monomeric glycoprotein belonging to the lipocalin superfamily. β-trace protein is constituted of 168 amino acids and has a low molecular weight of 23,000 to 29,000 Da, which depends on the degree of glycosylation. The β-trace protein has been reported to have a prostaglandin synthase activity (prostaglandin-H2 D-isomerase) and catalyzes the transformation of prostaglandin H2 (PGH2), which is a common precursor of various prostanoids, to prostaglandin D2 (PGD2). And PGD2 contributes to the sleep induction and regulation, nociception, adipocyte differentiation, bronchoconstriction, nitric oxide release, inflammatory mediator modulation, inhibition of platelet aggregation, and the induction of vasodilation. β-trace protein also has localized and specific functions that are responsible for the establishment and function of the blood-tissue barriers.

Summary diagram of β‐catenin showing the components involved in nuclear transport, gene regulation and cell–cell adhesion. And 3D structures of β‐catenin. Fig.1 Summary diagram of β‐catenin showing the components involved in nuclear transport, gene regulation and cell-cell adhesion. And 3D structures of β‐catenin. (Fagotto F, 2013)

The Diagnostic Application of β-trace protein in Kidney Diseases

In chronic kidney disease (CKD) patients, the measurement of GFR is critical to establish the stage of CKD and to lessen the burden of drug nephrotoxicity. Previous studies have demonstrated that urinary excretion of β-trace protein is increased in chronic kidney disease (CKD) patients from stage 2. β-trace protein was also revealed to be increased in the serum of patients with renal failure. Urinary excretion of β-trace protein is predominantly determined by its serum concentration and by the glomerular filtration rate (GFR) level, and to a lower extent by the excretion of urinary albumin. Serum BTP levels have been confirmed to have a good correlation with the GFR measurement through nuclear medicine and inulin clearance methods. Therefore, it has been regarded as a novel endogenous marker of glomerular filtration rate (GFR).

Cell‐adhesion‐dependent β‐catenin signaling. Fig.2 Cell‐adhesion‐dependent β‐catenin signaling. (Fagotto F, 2013)

IVD Antibody Development Services for β-trace Protein

In order to render more precise antibody-based diagnostic tools and assist clinicians in the diagnosis, prognosis, and staging of different diseases and infections, Creative Biolabs provides customized IVD antibody development services to generate high-quality antibodies for diagnostic usage. Besides antibody generation, we also offer antibody conjugation, antibody pairing, and diagnostic immunoassay development services to our clients. For more detailed information, please feel free to contact us or directly send us an inquiry.

Reference

  1. Fagotto F. (2013). “Looking beyond the Wnt pathway for the deep nature of β‐catenin.” EMBO reports, 14(5), 422-433.

For lab research use only.



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